KIN1400

Category	Hepatitis C Virus (HCV)
CAS	446826-86-4
Description	KIN1400 is an IRF3 activator with antiviral activity. It induces IRF3-dependent innate immune gene expression such as RIG-1, MDA5, IFIT1, IFIT2, IFITM1, OAS3, and Mx1 in THP-1 cells stimulated with phorbol 12-myristate 13-acetate (PMA). It also inhibits replication of HCV, West Nile virus, and Paramyxoviridae (RCV, NV).

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Synonyms	446826-86-4;KIN1400;KIN-1400;TCMDC-124379;7-[(2-benzothiazolylamino)[4-(difluoromethoxy)phenyl]methyl]-8-quinolinol;7-((benzo[d]thiazol-2-ylamino)(4-(difluoromethoxy)phenyl)methyl)quinolin-8-ol;7-[(1,3-BENZOTHIAZOL-2-YLAMINO)[4-(DIFLUOROMETHOXY)PHENYL]METHYL]QUINOLIN-8-OL;7-{(1,3-benzothiazol-2-ylamino)[4-(difluoromethoxy)phenyl]methyl}quinolin-8-ol;YDSHHDISKUSKFW-UHFFFAOYSA-N;CHEMBL548113;SCHEMBL17681899;GLXC-10002;STK966254;AKOS000808557;AKOS016290300;7-[(1,3-benzothiazol-2-ylamino)-[4-(difluoromethoxy)phenyl]methyl]quinolin-8-ol;DA-74765;HY-123805;KIN1400, >=98% (HPLC);CS-0085906;SR-03000002476;SR-03000002476-1;Z56842944;F1031-0168;
IUPAC Name	7-[(1,3-benzothiazol-2-ylamino)-[4-(difluoromethoxy)phenyl]methyl]quinolin-8-ol
Molecular Weight	449.47
Molecular Formula	C24H17F2N3O2S
Canonical SMILES	OC1=C2N=CC=CC2=CC=C1C(NC3=NC4=CC=CC=C4S3)C5=CC=C(OC(F)F)C=C5
InChI	InChI=1S/C24H17F2N3O2S/c25-23(26)31-16-10-7-15(8-11-16)20(29-24-28-18-5-1-2-6-19(18)32-24)17-12-9-14-4-3-13-27-21(14)22(17)30/h1-13,20,23,30H,(H,28,29)
InChIKey	YDSHHDISKUSKFW-UHFFFAOYSA-N
Purity	≥98%
Appearance	Solid
Storage	-20°C, sealed storage, away from moisture and light *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)