KDM2B-IN-1

Category	Influenza Virus
CAS	1965248-33-2
Description	KDM2B-IN-1 is a small molecule inhibitor specifically designed to target and inhibit KDM2B, a histone demethylase involved in regulating gene expression and cellular processes. By blocking KDM2B activity, this compound aims to influence epigenetic modifications, potentially offering therapeutic benefits in conditions where KDM2B plays a role, such as cancer and other diseases. KDM2B-IN-1 has been identified as a potential antiviral compound, particularly in the context of its activity against viruses such as Dengue virus. Research indicates that KDM2B-IN-1 can inhibit viral replication by targeting the KDM2B enzyme, which plays a role in the regulation of gene expression and viral gene activation.

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Synonyms	Piperazine, 1-cyclobutyl-4-[4,5-dihydro-1-[(5,6,7,8-tetrahydro-2-naphthalenyl)sulfonyl]-1H-imidazol-2-yl]-; 1-Cyclobutyl-4-[4,5-dihydro-1-[(5,6,7,8-tetrahydro-2-naphthalenyl)sulfonyl]-1H-imidazol-2-yl]piperazine; 1-Cyclobutyl-4-(1-((5,6,7,8-tetrahydronaphthalen-2-yl)sulfonyl)-4,5-dihydro-1H-imidazol-2-yl)piperazine; 1-Cyclobutyl-4-(1-tetralin-6-ylsulfonyl-4,5-dihydroimidazol-2-yl)piperazine
IUPAC Name	1-cyclobutyl-4-[1-(5,6,7,8-tetrahydronaphthalen-2-ylsulfonyl)-4,5-dihydroimidazol-2-yl]piperazine
Molecular Weight	402.56
Molecular Formula	C21H30N4O2S
Canonical SMILES	C1CCC2=C(C1)C=CC(=C2)S(=O)(=O)N3CCN=C3N4CCN(CC4)C5CCC5
InChI	InChI=1S/C21H30N4O2S/c26-28(27,20-9-8-17-4-1-2-5-18(17)16-20)25-11-10-22-21(25)24-14-12-23(13-15-24)19-6-3-7-19/h8-9,16,19H,1-7,10-15H2
InChIKey	JPPPBGVARYKPJW-UHFFFAOYSA-N
Boiling Point	556.6±60.0 °C at 760 mmHg
Purity	≥98% by HPLC
Density	1.41±0.1 g/cm3
Solubility	Soluble in DMSO
Appearance	White to beige solid
Storage	Store at 2-8 °C, protect from light, stored under nitrogen
Target	Cytochrome P450; Influenza Virus; DNA/RNA Synthesis Ki: 6.16 µM (RNA-dependent RNA polymerase)