Kaempferol

Category	Human immunodeficiency Virus (HIV)
CAS	520-18-3
Description	Kaempferol is a natural flavonol, a type of flavonoid, that has been isolated from plant sources. It has many functions such as anti-cancer, diuretic, anti-inflammatory, antioxidant, anti-bacterial, and anti-virus. Kaempferol can be used in food additive.

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Product Information

Synonyms	Robigenin; Kaempherol; Kempferol; Populnetin; Rhamnolutein
IUPAC Name	3,5,7-trihydroxy-2-(4-hydroxyphenyl)chromen-4-one
Molecular Weight	286.23
Molecular Formula	C15H10O6
Canonical SMILES	C1=CC(=CC=C1C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)O)O
InChI	InChI=1S/C15H10O6/c16-8-3-1-7(2-4-8)15-14(20)13(19)12-10(18)5-9(17)6-11(12)21-15/h1-6,16-18,20H
InChIKey	IYRMWMYZSQPJKC-UHFFFAOYSA-N
Boiling Point	582.1°C at 760 mmHg
Melting Point	276-278 °C
Flash Point	226.1°C
Purity	>98%
Density	1.688 g/cm3
Solubility	In Vitro: DMSO : ≥ 32 mg/mL(111.79 mM) H2O : < 0.1 mg/mL (ultrasonic;warming;heat to y information to select the appropriate solvent. In Vivo: 1.Add each solvent one by one:10% DMSO >> 40%PEG300 >> 5%Tween-80 >> 45% saline Solubility: ≥ 2 mg/mL (6.99 mM); Clear solution 2.Add each solvent one by one:10% DMSO >> 90% (20%SBE-β-CDin saline) Solubility: ≥ 2 mg/mL (6.99 mM); Clear solution 3.Add each solvent one by one:10% DMSO >> 90%corn oil Solubility: ≥ 2 mg/mL (6.99 mM); Clear solution
Appearance	yellow crystalline solid
Application	anti-inflammatory; diuretic; antioxidant; inhibitor of topoisomerase-ii;
Storage	-20°C
Complexity	451
Exact Mass	286.04773803
Index Of Refraction	1.785
In Vitro	Kaempferol also has anti-inflammatory effects via inhibition of interleukin-4 and cyclo-oxygenase 2 expression by suppressing Src kinase and downregulating the NFκB pathway. Kaempferol is also effective in inhibiting angiogenesis and inducing Apoptosis in ovarian cancer cells. Kaempferol is a natural flavonoid that is widely distributed in fruits and vegetables, and prospective studies revealed that over decades, consumption of Kaempferol dramatically and significantly reduces the risk of ovarian cancer in American female nurses. After a 24-hour treatment, Kaempferol causes a significant and concentration-dependent inhibition of proliferation in all 3 ovarian cancer cells tested. This inhibition is observed at 40 μM or higher concentrations of treatment. Kaempferol is a flavonoid which is abundant in a variety of plant derived food and leaves used in traditional medicines. Kaempferol significantly inhibits NADPH oxidase activity. Kaempferol decrease reactive oxygen species (ROS) by directly bound NADPH oxidase. Kaempferol prevents Ang II-induced sinus nodal cell death by lowering CAMKII oxidization.10-20 μM Kaempferol dose-dependently suppresses its release in sensitized RBL-2H3 cells. When 10-20 μM Kaempferol is supplemented to DNP-BSA-challenged RBL-2H3 cells for 15 min, the activation of Syk and PLCγ is highly attenuated. When ≥10 μM Kaempferol is added to DNP-BSA-challenged RBL-2H3 cells for 60 min, the COX2 induction is reduced.
In Vivo	The COX2 induction is confirmed in the airways of BSA-challenged BALB/c mice. There is lack of COX2 in airways of untreated control mice observed. The BSA inhalation to mice led to enhanced COX2 induction (dark brown staining) in mouse airway, which is reversed by oral administration of Kaempferol. In BSA-challenged mice, there is a marked goblet cell hyperplasia and epithelial thickening observed. When 20 mg/kg Kaempferol is supplemented to BSA-challenged mice, the epithelial thickening completely disappeared.
PSA	111.13
Target	Estrogen Receptor/ERR; Autophagy; Mitophagy; Apoptosis; HIV; Parasite;
Vapor Pressure	0.0±1.7 mmHg at 25°C
XLogP3-AA	1.9