K6PC-5

Category	Filovirus
CAS	756875-51-1
Description	K6PC-5 is a Sphingosine kinase 1 (SphK1 or SK1) activator that increases sphingosine-1-phosphate (S1P) production, an active metabolite of sphingolipid. S1P can modulate multiple cellular responses including [Ca2+] signaling, growth, survival, and differentiation. K6PC-5 regulates both differentiation and proliferation of keratinocytes via [Ca2+]i responses through S1P production, which may be used for the treatment of skin disorders characterized by abnormal differentiation and proliferation, such as atopic dermatitis and psoriasis.

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Synonyms	K6PC-5;756875-51-1;Dihydroxyisopropyl capryloylcaprylamide;N-(1,3-dihydroxypropan-2-yl)-2-hexyl-3-oxodecanamide;9UO46U4GM1;Decanamide, 2-hexyl-N-(2-hydroxy-1-(hydroxymethyl)ethyl)-3-oxo;2-Hexyl-N-[2-hydroxy-1-(hydroxymethyl)ethyl]-3-oxo-decanamide;UNII-9UO46U4GM1;SCHEMBL23149790;DTXSID50997113;AKOS040748654;DA-74700;K6PC-5, >=98% (HPLC);MS-25262;HY-124042;CS-0084020;F82343;Q27273251;N-(1,3-Dihydroxypropan-2-yl)-2-hexyl-3-oxodecanimidic acid;
IUPAC Name	N-(1,3-dihydroxypropan-2-yl)-2-hexyl-3-oxodecanamide
Molecular Weight	348.4
Molecular Formula	C19H16N4O3
Canonical SMILES	COCCN1C2=CC=CC=C2N=C3C1=NC(=O)N(C3=O)C4=CC=CC=C4
InChI	InChI=1S/C19H37NO4/c1-3-5-7-9-11-13-18(23)17(12-10-8-6-4-2)19(24)20-16(14-21)15-22/h16-17,21-22H,3-15H2,1-2H3,(H,20,24)
InChIKey	CGYVFCHCRBGGJG-UHFFFAOYSA-N
Purity	98%
Solubility	water, 2.052 mg/L @ 25 °C (est)
Appearance	Solid
Application	potential treatment of skin disorders with abnormal differentiation and proliferation