-
Antiviral API
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Junceellolide-C
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| Category | Hepatitis B Virus (HBV) |
| CAS | 121769-82-2 |
| Description | Junceellolide C is a transcription inhibitor of cccDNA. Junceellolide C inhibits HBV DNA replication and significantly decreases the level of supernatant HBV RNA with EC50 values of 5.19, 3.52 μM respectively in HepAD38 cells. Junceellolide C is a potent anti-HBV agent. |
Product Information
| Synonyms | Junceellolide C|Junceelloide C|CHEMBL4741387|HY-N10404|CS-0527534 |
| Molecular Weight | 540.99 |
| Molecular Formula | C26H33ClO10 |
| Canonical SMILES | CC1C(=O)OC2C1(C(C3C(C(CCC34CO4)OC(=O)C)(C(C=CC(=C)C2Cl)OC(=O)C)C)OC(=O)C)O |
| Purity | ≥98% (HPLC) |
| Solubility | In vitro: 10 mM in DMSO |
| Appearance | Solid powder |
| Storage | Store at -20°C |
| Complexity | 1060 |
| Exact Mass | 540.1762249 |
| In Vitro | Junceellolide C (10 μM; 72 hours) inhibits HBV DNA replication and significantly decreases the level of supernatant HBV RNA in HepAD38 cells with EC50 values of 2.27, 3.52 μM, respectively. Junceellolide C (10 μM; 8 days) can capable to inhibit HBV cccDNA replenishment and also to induce the existed HBV cccDNA degradation. |
| Target | EC50: 2.27 μM (HBV DNA replication), 3.52 μM (HBV RNA decrease) in HBeAg cells |
| XLogP3-AA | 1.7 |
