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(+)-JNJ-A07

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Category Virus Protease
CAS 2135640-93-4
Description (+)-JNJ-A07 is a highly potent, orally active pan-serotype dengue virus inhibitor targeting the NS3-NS4B interaction. (+)-JNJ-A07 exerts nanomolar to picomolar activity against a panel of 21 clinical isolates. (+)-JNJ-A07 has a favourable pharmacokinetic profile that results in outstanding efficacy against dengue virus infection in mouse infection models.
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Product Information

Molecular Weight 578.96
Molecular Formula C28H26ClF3N2O6
Purity 95.93%
Solubility In vitro:
10 mM in DMSO
Appearance Light yellow to brown (Solid)
Storage Powder:
-20°C: 3 years
4°C: 2 years
In solvent:
-80°C: 6 months
-20°C: 1 month
In Vitro (+)-JNJ-A07 has a high barrier to resistance and prevents the formation of the viral replication complex by blocking the interaction between two viral proteins (NS3 and NS4B).
Target Virus Protease

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