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Ivermectin B1a

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Category SARS-CoV
CAS 71827-03-7
Description It is the major component (>80%) of the commercial anthelmintic, ivermectin. It exerts its anthelmintic effects by binding to glutamate-gated chloride channels expressed on nematode neurones and pharyngeal muscle cells. It is also a potent insecticide.
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Product Information

Synonyms Ivermectin; Dihydroavermectin B1a; 22,23-Dihydroavermectin B1a; Ivermectin Component B1a; avermectin H2B1a; 5-O-demethyl-22,23-dihydroavermectin A1a; MK-933; Avermectin A1a, 5-O-demethyl-22,23-dihydro-; 22,23-Dihydroavermectin B(1)a; Spiro[11,15-methano-2H,13H,17H-furo[4,3,2-pq][2,6]benzodioxacyclooctadecin-13,2'-[2H]pyran], avermectin A1a deriv.; Ivermectin (IVM); IVM; dihydro avermectin Bla; H2B1a; Ivermectin (MK-0933)
IUPAC Name (1R,4S,5'S,6R,6'R,8R,10E,12S,13S,14E,20R,21R,24S)-6'-[(2S)-butan-2-yl]-21,24-dihydroxy-12-[(2R,4S,5S,6S)-5-[(2S,4S,5S,6S)-5-hydroxy-4-methoxy-6-methyloxan-2-yl]oxy-4-methoxy-6-methyloxan-2-yl]oxy-5',11,13,22-tetramethylspiro[3,7,19-trioxatetracyclo[15.6.1.14,8.020,24]pentacosa-10,14,16,22-tetraene-6,2'-oxane]-2-one
Molecular Weight 875.09
Molecular Formula C48H74O14
Canonical SMILES CC[C@H](C)[C@@H]1[C@H](CC[C@@]2(O1)C[C@@H]3C[C@H](O2)C/C=C(/[C@H]([C@H](/C=C/C=C4CO[C@H]5[C@@]4([C@@H](C=C([C@H]5O)C)C(=O)O3)O)C)O[C@H]6C[C@@H]([C@H]([C@@H](O6)C)O[C@H]7C[C@@H]([C@H]([C@@H](O7)C)O)OC)OC)\C)C
InChI InChI=1S/C48H74O14/c1-11-25(2)43-28(5)17-18-47(62-43)23-34-20-33(61-47)16-15-27(4)42(26(3)13-12-14-32-24-55-45-40(49)29(6)19-35(46(51)58-34)48(32,45)52)59-39-22-37(54-10)44(31(8)57-39)60-38-21-36(53-9)41(50)30(7)56-38/h12-15,19,25-26,28,30-31,33-45,49-50,52H,11,16-18,20-24H2,1-10H3/b13-12+,27-15+,32-14?/t25-,26-,28-,30-,31-,33+,34-,35-,36-,37-,38-,39-,40+,41-,42-,43+,44-,45+,47+,48+/m0/s1
InChIKey AZSNMRSAGSSBNP-MWEOTIHASA-N
Boiling Point 940.4±65.0°C at 760 mmHg
Melting Point 161-165°C
Purity >95% by HPLC
Density 1.2±0.1 g/cm3
Solubility Slightly soluble in Chloroform, DMSO
Appearance Solid
Storage Store at -20°C under inert atmosphere

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