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Antiviral API
- Arenavirus
- Cytomegalovirus (CMV)
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- Endogenous Metabolite
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- Human immunodeficiency Virus (HIV)
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- West Nile virus
- Antiviral intermediates
Influenza-virus-IN-4
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| Category | Influenza Virus |
| CAS | 2133818-85-4 |
| Description | Influenza virus-IN-4 (compound 11e) is a potent influenza virus neuraminidase inhibitor with IC50s of 3.4, 0.094, 0.79, 0.077 µM for H5N1, H5N2, H5N6, H5N8, respectively. Influenza virus-IN-4 shows NA (neuraminidase enzyme)-inhibitory activity. |
Product Information
| Synonyms | Influenza virus-IN-4|CHEMBL4788464|HY-146001|CS-0459581 |
| Molecular Weight | 418.5 |
| Molecular Formula | C23H31FN2O4 |
| Canonical SMILES | CCC(CC)OC1C=C(CC(C1NC(=O)C)NCC=CC2=CC=C(C=C2)F)C(=O)O |
| Purity | ≥98% (HPLC) |
| Solubility | In vitro: 10 mM in DMSO |
| Appearance | Solid powder |
| Storage | Store at -20°C |
| Complexity | 625 |
| Exact Mass | 418.22678564 |
| In Vitro | The influenza virus-IN-4 (compound 11e) showed NA (neuraminidase) inhibitory activity of 33.26, 16.81, 45.46, 33.02, 5270.33, 0.00043, 0.00347 nM against H5N1, H5N2, H5N1eH274Y, N1 (H1N1pdm09) and N2 (H3N2), respectively. |
| Target | IC50: 3.4 µM (H5N1); 0.094 µM (H5N2); 0.79 µM (H5N6); 0.077 µM (H5N8) |
| XLogP3-AA | 0.9 |
