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Antiviral API
- Arenavirus
- Cytomegalovirus (CMV)
- Dengue virus
- Endogenous Metabolite
- Enterovirus (EV)
- Epstein-Barr virus (EBV)
- Filovirus
- Flavivirus
- HCV Protease
- Hepatitis B Virus (HBV)
- Hepatitis C Virus (HCV)
- Herpes simplex Virus (HSV)
- HIF/HIF Prolyl-Hydroxylase
- HIV Integrase
- HIV Protease
- Human immunodeficiency Virus (HIV)
- Human papillomavirus (HPV)
- Influenza Virus
- Nipah virus
- Orthopoxvirus
- Others
- Rabies virus (RABV)
- Respiratory syncytial Virus (RSV)
- Reverse Transcriptases (RTs)
- SARS-CoV
- Tobacco mosaic virus (TMV)
- Vesicular stomatitis virus (VSV)
- Virus Protease
- West Nile virus
- Antiviral intermediates
INDOMETHACIN SODIUM
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| Category | Influenza Virus |
| CAS | 7681-54-1 |
| Description | Indomethacin (Indometacin) sodium is a potent, orally active COX1/2 inhibitor with IC50 values of 18 nM and 26 nM for COX-1 and COX-2, respectively. Indomethacin sodium has anticancer activity and anti-infective activity. Indomethacin sodium can be used for cancer, inflammation and viral infection research. |
Product Information
| Synonyms | 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1h-indole-3-aceticacisodiumsalt; 1-(p-chlorobenzoyl)-5-methoxy-2-methyl-indole-3-aceticacisodiumsalt; osmosin; sodium1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1h-indole-3-acetate; sodiumindomethacin; INDOMETHACIN SODIUM; 1-( |
| IUPAC Name | sodium;2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetate |
| Molecular Weight | 379.77 |
| Molecular Formula | C19H15ClNNaO4 |
| Canonical SMILES | CC1=C(C2=C(N1C(=O)C3=CC=C(C=C3)Cl)C=CC(=C2)OC)CC(=O)[O-].[Na+] |
| InChI | InChI=1S/C19H16ClNO4.Na/c1-11-15(10-18(22)23)16-9-14(25-2)7-8-17(16)21(11)19(24)12-3-5-13(20)6-4-12;/h3-9H,10H2,1-2H3,(H,22,23);/q;+1/p-1 |
| InChIKey | JMHRGKDWGWORNU-UHFFFAOYSA-M |
| Boiling Point | 499.4±45.0 °C at 760 mmHg |
| Melting Point | 162°C |
| Flash Point | 255.8±28.7 °C |
| Purity | 95% |
| Density | 1.3±0.1 g/cm3 |
| Solubility | In vitro: 10 mM in DMSO |
| Appearance | Solid powder |
| Storage | Store at -20°C |
| Complexity | 512 |
| Exact Mass | 379.0587299 |
| Index Of Refraction | 1.619 |
| In Vitro | Indomethacin (Indometacin) sodium (0-150 μM; 24 hours; 3LL-D122 cells) has anticancer activity in vitro. Indomethacin (Indometacin) sodium (0-1000 μM) protects the host cells from damage caused by the virus through activates PKR, resulting in elF2α phosphorylation, and in turn shutting of translation of viral protein and inhibiting replication of the virus (IC50=2μM). |
| In Vivo | Indomethacin (Indometacin) sodium (0.01-10 mg/kg; p.o.; for 3 hours; male Sprague-Dawley rats) induces paw oedema and hyperalgesmeasurement dose-dependently reversed carrageenan-induced hyperalgesia. Indomethacin (Indometacin) sodium (10 mg/mL; p.o.; daily, for 29 days; male C57BL/6J mice) inhibits tumor growth in vivo. |
| PSA | 99.05000 |
| Target | COX; Antibiotic; Influenza Virus |
| Vapor Pressure | 0.0±1.3 mmHg at 25°C |
