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Antiviral API
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Indometacin sodium
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| Category | Influenza Virus |
| CAS | 74252-25-8 |
| Description | Indomethacin sodium is the sodium salt of indomethacin, a non-selective, reversible, and competitive inhibitor of COX-1 and -2 with anti-inflammatory, analgesic-antipyretic and tocolytic effects. |
Product Information
| Synonyms | 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid sodium salt |
| IUPAC Name | sodium;2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetate;trihydrate |
| Molecular Weight | 433.82 |
| Molecular Formula | C19H21ClNNaO7 |
| Canonical SMILES | CC1=C(C2=C(N1C(=O)C3=CC=C(C=C3)Cl)C=CC(=C2)OC)CC(=O)[O-].O.O.O.[Na+] |
| InChI | InChI=1S/C19H16ClNO4.Na.3H2O/c1-11-15(10-18(22)23)16-9-14(25-2)7-8-17(16)21(11)19(24)12-3-5-13(20)6-4-12;;;;/h3-9H,10H2,1-2H3,(H,22,23);;3*1H2/q;+1;;;/p-1 |
| InChIKey | UHYAQBLOGVNWNT-UHFFFAOYSA-M |
| Boiling Point | 499.4±45.0 °C at 760 mmHg |
| Melting Point | 162°C |
| Flash Point | 255.8±28.7 °C |
| Purity | ≥98% (HPLC) |
| Density | 1.3±0.1 g/cm3 |
| Solubility | In Vitro: H2O : 25 mg/mL(57.63 mM;Need ultrasonic) DMSO : 12.5 mg/mL(28.81 mM;ultrasonic and warming and heat to 60°C) In Vivo: 1.Add each solvent one by one:10% DMSO >> 40%PEG300 >> 5%Tween-80 >> 45% saline Solubility: ≥ 2.08 mg/mL (4.79 mM); Clear solution 2.Add each solvent one by one:10% DMSO >> 90% (20%SBE-β-CD in saline) Solubility: ≥ 2.08 mg/mL (4.79 mM); Clear solution |
| Appearance | Light yellow to yellow (Solid) |
| Storage | 4°C, protect from light, stored under nitrogen * In solvent : -80°C 6 months; -20°C 1 month (protect from light, stored under nitrogen) |
| Index Of Refraction | 1.619 |
| In Vitro | Indomethacin (Indometacin) sodium hydrateis (0-150 μM; 24 hours; 3LL-D122 cells) has anticancer activity in vitro. Indomethacin (Indometacin) sodium hydrateis (0-1000 μM) protects the host cells from damage caused by the virus through activates PKR, resulting in elF2α phosphorylation, and in turn shutting of translation of viral protein and inhibiting replication of the virus (IC50=2 μM). |
| In Vivo | Indomethacin (Indometacin) sodium hydrateis (0.01-10 mg/kg; p.o.; for 3 hours; male Sprague-Dawley rats) induces paw oedema and hyperalgesmeasurement dose-dependently reversed carrageenan-induced hyperalgesia. Indomethacin (Indometacin) sodium hydrateis (10 mg/mL; p.o.; daily, for 29 days; male C57BL/6J mice) inhibits tumor growth in vivo. |
| PSA | 99.05000 |
| Target | COX; Bacterial; Influenza Virus |
| Vapor Pressure | 0.0±1.3 mmHg at 25°C |
