-
Antiviral API
- Arenavirus
- Cytomegalovirus (CMV)
- Dengue virus
- Endogenous Metabolite
- Enterovirus (EV)
- Epstein-Barr virus (EBV)
- Filovirus
- Flavivirus
- HCV Protease
- Hepatitis B Virus (HBV)
- Hepatitis C Virus (HCV)
- Herpes simplex Virus (HSV)
- HIF/HIF Prolyl-Hydroxylase
- HIV Integrase
- HIV Protease
- Human immunodeficiency Virus (HIV)
- Human papillomavirus (HPV)
- Influenza Virus
- Nipah virus
- Orthopoxvirus
- Others
- Rabies virus (RABV)
- Respiratory syncytial Virus (RSV)
- Reverse Transcriptases (RTs)
- SARS-CoV
- Tobacco mosaic virus (TMV)
- Vesicular stomatitis virus (VSV)
- Virus Protease
- West Nile virus
- Antiviral intermediates
IMB-301
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| Category | Human immunodeficiency Virus (HIV) |
| CAS | 64009-84-3 |
| Description | IMB-301 is a specific HIV-1 replication inhibitor that binds to hA3G (human APOBEC3G, a restriction factor that inhibits human immunodeficiency 1 virus (HIV-1) replication), blocks hA3G-Vif interaction and inhibits Vif-mediated hA3G degradation. It inhibits HIV-1 replication in H9 cells with an IC50 of 8.63 uM. |
Product Information
| Synonyms | NSC301209; 1-[2-(2,4-dichlorophenyl)-4-(4-fluorophenoxy)butyl]imidazole; 3-(2,4-Dichlorophenyl)-4-(1H-imidazol-1-yl)butyl 4-fluorophenyl ether; 1H-Imidazole, 1-[2-(2,4-dichlorophenyl)-4-(4-fluorophenoxy)butyl]- |
| IUPAC Name | 1-[2-(2,4-dichlorophenyl)-4-(4-fluorophenoxy)butyl]imidazole |
| Molecular Weight | 379.26 |
| Molecular Formula | C19H17Cl2FN2O |
| Canonical SMILES | C1=CC(=CC=C1OCCC(CN2C=CN=C2)C3=C(C=C(C=C3)Cl)Cl)F |
| InChI | InChI=1S/C19H17Cl2FN2O/c20-15-1-6-18(19(21)11-15)14(12-24-9-8-23-13-24)7-10-25-17-4-2-16(22)3-5-17/h1-6,8-9,11,13-14H,7,10,12H2 |
| InChIKey | FHKXBOJPHOEMQO-UHFFFAOYSA-N |
| Boiling Point | 548.1±50.0°C (Predicted) |
| Flash Point | 285.3°C |
| Purity | ≥95% |
| Density | 1.27±0.1 g/cm3 (Predicted) |
| Solubility | Soluble in DMSO |
| Appearance | Colorless to light yellow (Oil) |
| Storage | Store at -20°C |
| Complexity | 396 |
| Exact Mass | 378.0701967 |
| Index Of Refraction | 1.589 |
| In Vitro | IMB-301 is able to increase virion encapsidation of hA3G via its ability to impair the degradation of hA3Gby Vif, which results in hA3G-dependent anti-HIV activity. IMB-301 binds to hA3G, restores hA3G expression in the presence of Vif, and inhibits the replication of HIV-1 in a hA3G-dependent manner. |
| PSA | 27.05000 |
| Target | HIV |
| XLogP3-AA | 5.1 |
