Idoxuridine

Category	Herpes simplex Virus (HSV)
CAS	54-42-2
Description	5-Iodo-2'-deoxyuridine is a nucleoside analog that can be incorporated into viral DNA replication to treat herpes simplex keratitis.

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Synonyms	5-Iodo-2'-deoxyuridine; IDU; 2'-Deoxy-5-iodouridine; 5-Iodo-2'-deoxy-D-uridine; 1-(2-Deoxy-β-D-ribofuranosyl)-5-iodouracil; IUdR; Dendrid; Emanil; NSC 39661; Ophthalmadine; Herpesil; Herpidu; Herplex; Stoxil; Stoxip; Synmiol; Virudox
IUPAC Name	1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-iodopyrimidine-2,4-dione
Molecular Weight	354.10
Molecular Formula	C9H11IN2O5
Canonical SMILES	C1C(C(OC1N2C=C(C(=O)NC2=O)I)CO)O
InChI	InChI=1S/C9H11IN2O5/c10-4-2-12(9(16)11-8(4)15)7-1-5(14)6(3-13)17-7/h2,5-7,13-14H,1,3H2,(H,11,15,16)/t5-,6+,7+/m0/s1
InChIKey	XQFRJNBWHJMXHO-RRKCRQDMSA-N
Melting Point	>160°C (dec.)
Purity	≥98% by HPLC
Density	2.14±0.1 g/cm3
Solubility	Soluble in DMSO (Slightly, Sonicated), Methanol (Slightly, Heated), Water (Slightly, Heated
Appearance	White Crystalline Powder
Application	5-Iodo-2'-deoxyuridine is a nucleoside analog treat herpes simplex keratitis.
Storage	Store at -20°C
Complexity	386
Exact Mass	353.97127
Index Of Refraction	1.715
In Vitro	Idoxuridine (2-10 μM, 72 hours) has the IC50 value of 4.3 μM of antiviral.
In Vivo	Idoxuridine (intraperitoneal injection, 50-200 mg/kg, 3 times, 3 hours interval) can stimulate the production of hemolysin plaque-forming cells (HPFC) to sheep red blood cells (SRBC) in C3HeB/FeJ female and male mice and A/J male mice.
PSA	104.55000
Target	Phosphatase; Orthopoxvirus
XLogP3-AA	-1