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Antiviral API
- Arenavirus
- Cytomegalovirus (CMV)
- Dengue virus
- Endogenous Metabolite
- Enterovirus (EV)
- Epstein-Barr virus (EBV)
- Filovirus
- Flavivirus
- HCV Protease
- Hepatitis B Virus (HBV)
- Hepatitis C Virus (HCV)
- Herpes simplex Virus (HSV)
- HIF/HIF Prolyl-Hydroxylase
- HIV Integrase
- HIV Protease
- Human immunodeficiency Virus (HIV)
- Human papillomavirus (HPV)
- Influenza Virus
- Nipah virus
- Orthopoxvirus
- Others
- Rabies virus (RABV)
- Respiratory syncytial Virus (RSV)
- Reverse Transcriptases (RTs)
- SARS-CoV
- Tobacco mosaic virus (TMV)
- Vesicular stomatitis virus (VSV)
- Virus Protease
- West Nile virus
- Antiviral intermediates
HZ-1157
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| Category | HCV Protease |
| CAS | 1009734-33-1 |
| Description | HZ-1157 is an inhibitor of hepatitis C virus (HCV) nonstructural protein 3/4A (NS3/4A) protease. |
Product Information
| Synonyms | HZ-1157; HZ 1157; HZ1157. Dengue Virus Inhibitor II; 5-tert-butoxyquinazoline-2,4-diamine; 5-(tert-Butoxy)quinazoline-2,4-diamine; 2,4-Quinazolinediamine, 5-(1,1-dimethylethoxy)- |
| Molecular Weight | 232.287 |
| Molecular Formula | C12H16N4O |
| Canonical SMILES | CC(C)(C)OC1=CC=CC2=C1C(=NC(=N2)N)N |
| InChI | InChI=1S/C12H16N4O/c1-12(2,3)17-8-6-4-5-7-9(8)10(13)16-11(14)15-7/h4-6H,1-3H3,(H4,13,14,15,16) |
| InChIKey | JQHKDYFLRJIBLX-UHFFFAOYSA-N |
| Boiling Point | 471.6±53.0 °C at 760 mmHg |
| Flash Point | 239.0±30.9 °C |
| Purity | 98.75% |
| Density | 1.2±0.1 g/cm3 |
| Solubility | In Vitro: DMSO : 20 mg/mL(86.10 mM;Need ultrasonic) In Vivo: 1.Add each solvent one by one:10% DMSO >> 40%PEG300 >> 5%Tween-80 >> 45% saline Solubility: ≥ 2 mg/mL (8.61 mM); Clear solution 2.Add each solvent one by one:10% DMSO >> 90% (20%SBE-β-CD in saline) Solubility: ≥ 2 mg/mL (8.61 mM); Clear solution 3.Add each solvent one by one:10% DMSO >> 90%corn oil Solubility: ≥ 2 mg/mL (8.61 mM); Clear solution |
| Appearance | White to light yellow (Solid) |
| Storage | Powder: -20°C: 3 years 4°C: 2 years In solvent: -80°C: 6 months -20°C: 1 month |
| Complexity | 266 |
| Exact Mass | 232.13241115 |
| Index Of Refraction | 1.658 |
| In Vitro | HZ-1157 (4a) is known to possess a broad spectrum of biological activities, such as protein lysine methyltransferase G9a inhibition, SMN2 promoter activation, dihydrofolate reductase inhibition, and others. Result: Inhibited HCV infection in vitro with an IC50 of 0.82 μmol/L |
| PSA | 87.05000 |
| Target | HCV Protease |
| Vapor Pressure | 0.0±1.2 mmHg at 25°C |
| XLogP3-AA | 1.8 |
