Hypericin

Category	Hepatitis C Virus (HCV)
CAS	548-04-9
Description	It is a natural antidepressant produced by the strain of Hypericium perforatum (plant extract). It is an anti-retroviral agent and protein kinaze-C inhibitor.

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Product Information

Synonyms	Cyclo-Werol; Cyclosan; Hyperflav; Hypericum red; NSC 407313; Mycoporphyrin; 4,5,7,4',5',7'-Hexahydroxy-2,2'-dimethylnaphthodianthrone; 1:6:8:10:11:13-hexahydroxy-3:4-dimethyl-meso-naphthodianthrene-7:14-dione
IUPAC Name	1,3,4,6,8,13-hexahydroxy-10,11-dimethylphenanthro[1,10,9,8-opqra]perylene-7,14-dione
Molecular Weight	504.45
Molecular Formula	C30H16O8
Canonical SMILES	CC1=CC(=C2C3=C1C4=C5C(=C(C=C4C)O)C(=O)C6=C(C=C(C7=C6C5=C3C8=C7C(=CC(=C8C2=O)O)O)O)O)O
InChI	InChI=1S/C30H16O8/c1-7-3-9(31)19-23-15(7)16-8(2)4-10(32)20-24(16)28-26-18(12(34)6-14(36)22(26)30(20)38)17-11(33)5-13(35)21(29(19)37)25(17)27(23)28/h3-6,31-36H,1-2H3
InChIKey	BTXNYTINYBABQR-UHFFFAOYSA-N
Boiling Point	1020.3±65.0 °C \| Condition: Press: 760 Torr
Melting Point	299-301°C
Flash Point	530.1±30.8 °C
Purity	>98%
Density	1.915±0.06 g/cm3 \| Condition: Temp: 20 °C Press: 760 Torr
Solubility	Soluble in DMSO (Slightly), Methanol (Slightly, Heated)
Appearance	Very Dark Red to Black Solid
Application	Antineoplastic and antitumor
Storage	Store at RT
Complexity	1090
Exact Mass	504.08451746
Index Of Refraction	2.131
In Vitro	Hypericin (0.25-4 μM; 24 h) inhibits the growth of fibroblasts (Fb), melanocytes (Mc), and keratinocytes (Kc). Hypericin (3 μM; 24 h) treatment can induce cells Apoptosis. Result: Showed the LD50 for Fb and Mc at 1.75 μM and 3.5 μM, respectively, and for Kc at a greater dose than 4 μM.
In Vivo	Hypericin (0.25-4 μM; 24 h) inhibits the growth of fibroblasts (Fb), melanocytes (Mc), and keratinocytes (Kc).
PSA	155.52000
Target	Apoptosis; Influenza Virus; Antibiotic; Monoamine Oxidase; PKC; Cytochrome P450;
Vapor Pressure	0.0±0.3 mmHg at 25°C
XLogP3-AA	5.7