Hydroxychloroquine

Category	SARS-CoV
CAS	118-42-3
Description	Hydroxychloroquine is a synthetic antimalarial agent and it can inhibit Toll-like receptor 7/9 (TLR7/9) signaling. Hydroxychloroquine efficiently inhibits SARS-CoV-2 infection in vitro.

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Synonyms	Plaquenil; Oxichloroquine; Polirreumin; 7-Chloro-4-(4-(ethyl(2-hydroxyethyl)amino)-1-methylbutylamino)quinoline; WIN 1258; Win 1258-2
IUPAC Name	2-[4-[(7-chloroquinolin-4-yl)amino]pentyl-ethylamino]ethanol
Molecular Weight	335.87
Molecular Formula	C18H26ClN3O
Canonical SMILES	CCN(CCCC(C)NC1=C2C=CC(=CC2=NC=C1)Cl)CCO
InChI	InChI=1S/C18H26ClN3O/c1-3-22(11-12-23)10-4-5-14(2)21-17-8-9-20-18-13-15(19)6-7-16(17)18/h6-9,13-14,23H,3-5,10-12H2,1-2H3,(H,20,21)
InChIKey	XXSMGPRMXLTPCZ-UHFFFAOYSA-N
Boiling Point	516.7°C at 760 mmHg
Melting Point	91-93°C
Flash Point	266.3°C
Purity	≥97%
Density	1.176 g/cm3
Solubility	Soluble in Chloroform (Slightlly), DMSO (Slightly), Methanol (Slightly)
Appearance	White to Off-white Solid
Application	Antimalarials
Storage	Powder: -20°C: 3 years 4°C: 2 years In solvent: -80°C: 6 months -20°C: 1 month
Complexity	331
Exact Mass	335.1764402
Index Of Refraction	1.5790 (estimate)
PSA	48.39000
Target	Parasite; Toll-like Receptor (TLR); SARS-CoV; Autophagy
Vapor Pressure	1.68E-11mmHg at 25°C
XLogP3-AA	3.6