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Antiviral API
- Arenavirus
- Cytomegalovirus (CMV)
- Endogenous Metabolite
- Enterovirus (EV)
- Epstein-Barr virus (EBV)
- Filovirus
- HCV Protease
- Hepatitis B Virus (HBV)
- Hepatitis C Virus (HCV)
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- HIF/HIF Prolyl-Hydroxylase
- HIV Integrase
- HIV Protease
- Human immunodeficiency Virus (HIV)
- Human papillomavirus (HPV)
- Influenza Virus
- Orthopoxvirus
- Others
- Respiratory syncytial Virus (RSV)
- Reverse Transcriptases (RTs)
- SARS-CoV
- Virus Protease
- Antiviral intermediates
HY-17542
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| Category | SARS-CoV |
| CAS | 1093070-14-4 |
| Description | HY-17542 is a potent inhibitor of papain-like protease (PLpro) with IC50 of 2.6 μM. |
Product Information
| Synonyms | PLpro inhibitor 6; (R)-5-acetamido-2-methyl-N-(1-(naphthalen-1-yl)ethyl)benzamide; HY 17542; HY17542 |
| IUPAC Name | 5-acetamido-2-methyl-N-[(1R)-1-naphthalen-1-ylethyl]benzamide |
| Molecular Weight | 346.43 |
| Molecular Formula | C22H22N2O2 |
| Canonical SMILES | CC1=C(C=C(C=C1)NC(=O)C)C(=O)NC(C)C2=CC=CC3=CC=CC=C32 |
| InChI | InChI=1S/C22H22N2O2/c1-14-11-12-18(24-16(3)25)13-21(14)22(26)23-15(2)19-10-6-8-17-7-4-5-9-20(17)19/h4-13,15H,1-3H3,(H,23,26)(H,24,25)/t15-/m1/s1 |
| InChIKey | KGPYBLOBHQLIET-OAHLLOKOSA-N |
| Purity | >98% |
| Solubility | In vitro: 10 mM in DMSO |
| Appearance | White to off-white (Solid) |
| Complexity | 506 |
| Exact Mass | 346.168127949 |
| In Vitro | PLpro inhibitor is a potent inhibitor against the papain-like protease (PLpro) from the coronavirus that causes severe acute respiratory syndrome (SARS-CoV). PLpro inhibitor was found to have IC50 value of 2.6 ± 0.1 μM. PLpro inhibitor display significant antiviral activity with EC50 values of 13.1±0.7 uM, without toxicity up to the highest concentration tested. Notably, the increasing antiviral potency correlates with the in vitro inhibition of PLpro, suggesting that the compounds work directly on the enzyme in cells. |
| PSA | 65.18000 |
| Target | SARS-CoV |
| XLogP3-AA | 3.9 |
