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Antiviral API
- Arenavirus
- Cytomegalovirus (CMV)
- Endogenous Metabolite
- Enterovirus (EV)
- Epstein-Barr virus (EBV)
- Filovirus
- HCV Protease
- Hepatitis B Virus (HBV)
- Hepatitis C Virus (HCV)
- Herpes simplex Virus (HSV)
- HIF/HIF Prolyl-Hydroxylase
- HIV Integrase
- HIV Protease
- Human immunodeficiency Virus (HIV)
- Human papillomavirus (HPV)
- Influenza Virus
- Orthopoxvirus
- Others
- Respiratory syncytial Virus (RSV)
- Reverse Transcriptases (RTs)
- SARS-CoV
- Virus Protease
- Antiviral intermediates
HSP90-IN-14
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| Category | Influenza Virus |
| CAS | 1995132-67-6 |
| Description | HSP90-IN-14 (compound 4) is a potent Hsp90 (heat shock protein 90) inhibitor, with a Kd of 0.26 μM. HSP90-IN-14 shows anti-influenza virus activity in MDCK cells, with EC50 values of 2.6, 3.9, and 17 μM for influenza A/H3N2, A/H1N1, and B, respectively. |
Product Information
| Synonyms | CHEMBL3931016|HSP90-IN-14|BDBM50198235|HY-147974|CS-0530512 |
| Molecular Weight | 399.21 |
| Molecular Formula | C14H8Cl2N4O4S |
| Canonical SMILES | C1=CC2=C(C=C1NC(=O)C(=O)O)SC(=N2)NC(=O)C3=CC(=C(N3)Cl)Cl |
| Purity | ≥98% (HPLC) |
| Solubility | In vitro: 10 mM in DMSO |
| Appearance | Solid powder |
| Storage | Store at -20°C |
| Complexity | 569 |
| Exact Mass | 397.9643313 |
| In Vitro | HSP90-IN-14 (compound 4) (50 µM) inhibits influenza virus-induced cytopathic effect at non-toxic concentration. |
| Target | HSP90β:0.26 ± 0.0 μM (Kd); Influenza Virus |
| XLogP3-AA | 3.4 |
