HIV-1-inhibitor-6

Category	Human immunodeficiency Virus (HIV)
CAS	1821309-39-0
Description	HIV-1 inhibitor-6 (compound 9), a diheteroarylamide-based compound, is a potent HIV-1 pre-mRNA alternative splicing inhibitor. HIV-1 inhibitor-6 blocks HIV replication. HIV-1 inhibitor-6 is active against wild-type HIV-1IIIB (subtype B, X4-tropic) and HIV-1 97USSN54 (subtype A, R5-tropic) with EC50s of 0.6 μM and 0.9 μM, respectively. HIV-1 inhibitor-6 inhibits HIV strains resistant to drugs targeting HIV reverse transcriptase, protease, integrase, and coreceptor CCR5 with EC50s ranging from 0.9 to 1.5 μM.

Quotation Now

Synonyms	HIV-1 inhibitor-6\|CHEMBL3786251\|SCHEMBL17233990\|NSC805574\|NSC-805574\|HY-134851\|J3.609.220C\|1-methyl-N-(5-nitro-1,2-benzothiazol-3-yl)-4-oxo-pyridine-3-carboxamide\|N-(5-Nitro-1,2-benzoisothiazole-3-yl)-1,4-dihydro-1-methyl-4-oxopyridine-3-carboxamide
Molecular Weight	330.32
Molecular Formula	C14H10N4O4S
Canonical SMILES	CN1C=CC(=O)C(=C1)C(=O)NC2=NSC3=C2C=C(C=C3)[N+](=O)[O-]
Purity	98.91%
Solubility	In Vitro: DMSO : 3.33 mg/mL(10.08 mM;ultrasonic and warming and heat to 80°C)
Appearance	Yellow to orange (Solid)
Storage	Powder: -20°C: 3 years 4°C: 2 years In solvent: -80°C: 6 months -20°C: 1 month
Complexity	600
Exact Mass	330.04227599
Target	X4 HIV-1 (IIIB):0.6 μM (EC50) R5 HIV-1:0.9 μM (EC50)
XLogP3-AA	1.9