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Antiviral API
- Arenavirus
- Cytomegalovirus (CMV)
- Endogenous Metabolite
- Enterovirus (EV)
- Epstein-Barr virus (EBV)
- Filovirus
- HCV Protease
- Hepatitis B Virus (HBV)
- Hepatitis C Virus (HCV)
- Herpes simplex Virus (HSV)
- HIF/HIF Prolyl-Hydroxylase
- HIV Integrase
- HIV Protease
- Human immunodeficiency Virus (HIV)
- Human papillomavirus (HPV)
- Influenza Virus
- Orthopoxvirus
- Others
- Respiratory syncytial Virus (RSV)
- Reverse Transcriptases (RTs)
- SARS-CoV
- Virus Protease
- Antiviral intermediates
HIV-1-inhibitor-6
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| Category | Human immunodeficiency Virus (HIV) |
| CAS | 1821309-39-0 |
| Description | HIV-1 inhibitor-6 (compound 9), a diheteroarylamide-based compound, is a potent HIV-1 pre-mRNA alternative splicing inhibitor. HIV-1 inhibitor-6 blocks HIV replication. HIV-1 inhibitor-6 is active against wild-type HIV-1IIIB (subtype B, X4-tropic) and HIV-1 97USSN54 (subtype A, R5-tropic) with EC50s of 0.6 μM and 0.9 μM, respectively. HIV-1 inhibitor-6 inhibits HIV strains resistant to drugs targeting HIV reverse transcriptase, protease, integrase, and coreceptor CCR5 with EC50s ranging from 0.9 to 1.5 μM. |
Product Information
| Synonyms | HIV-1 inhibitor-6|CHEMBL3786251|SCHEMBL17233990|NSC805574|NSC-805574|HY-134851|J3.609.220C|1-methyl-N-(5-nitro-1,2-benzothiazol-3-yl)-4-oxo-pyridine-3-carboxamide|N-(5-Nitro-1,2-benzoisothiazole-3-yl)-1,4-dihydro-1-methyl-4-oxopyridine-3-carboxamide |
| Molecular Weight | 330.32 |
| Molecular Formula | C14H10N4O4S |
| Canonical SMILES | CN1C=CC(=O)C(=C1)C(=O)NC2=NSC3=C2C=C(C=C3)[N+](=O)[O-] |
| Purity | 98.91% |
| Solubility | In Vitro: DMSO : 3.33 mg/mL(10.08 mM;ultrasonic and warming and heat to 80°C) |
| Appearance | Yellow to orange (Solid) |
| Storage | Powder: -20°C: 3 years 4°C: 2 years In solvent: -80°C: 6 months -20°C: 1 month |
| Complexity | 600 |
| Exact Mass | 330.04227599 |
| Target | X4 HIV-1 (IIIB):0.6 μM (EC50) R5 HIV-1:0.9 μM (EC50) |
| XLogP3-AA | 1.9 |
