HIV-1-inhibitor-43

Category	Human immunodeficiency Virus (HIV)
CAS	2493426-43-8
Description	HIV-1 inhibitor-43 is a potent HIV-1 inhibitor with an EC50 of 21.3 nM, 6.2 nM, < 0.7 nM and < 0.7 nM for Y188L, K103N-Y181C, K103N and Y181C, respectively. HIV-1 inhibitor-43 can reduce HIV-1 RNA and protein p24 expression.

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Synonyms	HIV-1 inhibitor-43\|CHEMBL4784247\|BDBM50556159\|HY-150599\|CS-0534824\|5-chloro-3-(3,5-dimethylphenyl)sulfonyl-N-[(2-hydroxyphenyl)methyl]-1H-indole-2-carboxamide
Molecular Weight	468.95
Molecular Formula	C24H21ClN2O4S
Canonical SMILES	CC1=CC(=CC(=C1)S(=O)(=O)C2=C(NC3=C2C=C(C=C3)Cl)C(=O)NCC4=CC=CC=C4O)C
Purity	≥98% (HPLC)
Solubility	10 mM in DMSO
Appearance	Solid powder
Storage	Store at -20°C
Complexity	763
Exact Mass	468.0910560
In Vitro	HIV-1 inhibitor-43 (compound 12) has anti-HIV-1 activity against HIV-1 reverse transcriptase with IC50s of 83±8 nM, 73±8 nM, 61±6 nM and 76±8 nM for HIV-1 WT, K103N, Y181I and K103N-Y181I, respectively. HIV-1 inhibitor-43 (1, 5 and 25 nM) causes 100% reduction of HIV-1 RNA and protein p24 at 25 nM in C8166 cells infected with a WT strain.
Target	HIV-1 (Y188L):21.3 nM (EC50) HIV-1 (K103N+Y181C):6.2 nM (EC50) HIV-1 (K103N):<0.7 nM (EC50) HIV-1 (Y181C):<0.7 nM (EC50)
XLogP3-AA	5.5