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Antiviral API
- Arenavirus
- Cytomegalovirus (CMV)
- Dengue virus
- Endogenous Metabolite
- Enterovirus (EV)
- Epstein-Barr virus (EBV)
- Filovirus
- Flavivirus
- HCV Protease
- Hepatitis B Virus (HBV)
- Hepatitis C Virus (HCV)
- Herpes simplex Virus (HSV)
- HIF/HIF Prolyl-Hydroxylase
- HIV Integrase
- HIV Protease
- Human immunodeficiency Virus (HIV)
- Human papillomavirus (HPV)
- Influenza Virus
- Nipah virus
- Orthopoxvirus
- Others
- Rabies virus (RABV)
- Respiratory syncytial Virus (RSV)
- Reverse Transcriptases (RTs)
- SARS-CoV
- Tobacco mosaic virus (TMV)
- Vesicular stomatitis virus (VSV)
- Virus Protease
- West Nile virus
- Antiviral intermediates
HIV-1-inhibitor-41
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| Category | Human immunodeficiency Virus (HIV) |
| Description | HIV-1 inhibitor-41 (Compound B23) is an orally active non-nucleoside HIV-1 reverse transcriptase inhibitor with EC50 values of 20.8 nM and 50 nM against HIV-1 WT and mutant E138K strain, respectively. HIV-1 inhibitor-41 shows low hERG, no apparent CYP enzymatic inhibition and no acute toxicity. |
Product Information
| Synonyms | HIV-1 inhibitor-41|HY-147841 |
| Molecular Weight | 335.37 |
| Molecular Formula | C16H15F2N3OS |
| Canonical SMILES | CC1=C(N=C(NC1=O)SC(C)C)C(C#N)C2=C(C=CC=C2F)F |
| Purity | ≥98% (HPLC) |
| Solubility | 10 mM in DMSO |
| Appearance | Solid powder |
| Storage | Store at -20°C |
| Complexity | 583 |
| Exact Mass | 335.09038961 |
| Target | HIV-1 (WT): 20.8 nM (IC50) HIV-1 (E138K): 50 nM (IC50) HIV-1 (Y181C): 0.75 μM (IC50) HIV-1 (L100I): 1.03 μM (IC50) HIV-1 (K103N): 3.39 μM (IC50) HIV-1 (Y188L): 69.04 μM (IC50) |
| XLogP3-AA | 3 |
