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Antiviral API
- Arenavirus
- Cytomegalovirus (CMV)
- Endogenous Metabolite
- Enterovirus (EV)
- Epstein-Barr virus (EBV)
- Filovirus
- HCV Protease
- Hepatitis B Virus (HBV)
- Hepatitis C Virus (HCV)
- Herpes simplex Virus (HSV)
- HIF/HIF Prolyl-Hydroxylase
- HIV Integrase
- HIV Protease
- Human immunodeficiency Virus (HIV)
- Human papillomavirus (HPV)
- Influenza Virus
- Orthopoxvirus
- Others
- Respiratory syncytial Virus (RSV)
- Reverse Transcriptases (RTs)
- SARS-CoV
- Virus Protease
- Antiviral intermediates
HIV-1-inhibitor-25
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| Category | Human immunodeficiency Virus (HIV) |
| CAS | 2475658-74-1 |
| Description | HIV-1 inhibitor-25 (compound R-12a) is a highly potent HIV-1 reverse transcriptase, with an IC50 value of 0.1061 μM. HIV-1 inhibitor-25 has high antiretroviral activity against WT HIV-1 with an EC50 of 13.6 nM, and exhibits relatively low cytotoxicity with a CC50 of 33.13 μM in MT-4 cells. HIV-1 inhibitor-25 also has inhibitory activity against HIV-1 mutant strains (L100I, K103N, Y181C, Y188L, E138K, F227L+V106A) with EC50 of 0.1961 ~ 5.8136 μM. HIV-1 inhibitor-25 can be used for researching AIDS. |
Product Information
| Synonyms | HIV-1 inhibitor-25|CHEMBL4783133|BDBM50565312|HY-146019A|CS-0494940 |
| Molecular Weight | 433.46 |
| Molecular Formula | C26H19N5O2 |
| Canonical SMILES | COC1=C(C=CC(=C1)C2=CC=C(C=C2)C#N)C(C3=NC(=NC=C3)NC4=CC=C(C=C4)C#N)O |
| Purity | ≥98% (HPLC) |
| Solubility | 10 mM in DMSO |
| Appearance | Solid powder |
| Storage | Store at -20°C |
| Complexity | 713 |
| Exact Mass | 433.15387487 |
| Target | HIV (IIIB):13.6 nM (EC50) HIV-1 (L100I):1.2458 ± 0 μM (EC50) HIV-1 (K103N):0.4383 ± 0 μM (EC50) HIV-1 (Y181C):0.5075 ± 0 μM (EC50) HIV-1 (Y188L):5.8136 ± 2 μM (EC50) HIV-1 (E138K):0.1961 ± 0 μM (EC50) HIV-1 (F227L+V106A):3.0683 ± 0 μM (EC50) |
| XLogP3-AA | 4 |
