HIV-1-inhibitor-25

Category	Human immunodeficiency Virus (HIV)
CAS	2475658-74-1
Description	HIV-1 inhibitor-25 (compound R-12a) is a highly potent HIV-1 reverse transcriptase, with an IC50 value of 0.1061 μM. HIV-1 inhibitor-25 has high antiretroviral activity against WT HIV-1 with an EC50 of 13.6 nM, and exhibits relatively low cytotoxicity with a CC50 of 33.13 μM in MT-4 cells. HIV-1 inhibitor-25 also has inhibitory activity against HIV-1 mutant strains (L100I, K103N, Y181C, Y188L, E138K, F227L+V106A) with EC50 of 0.1961 ~ 5.8136 μM. HIV-1 inhibitor-25 can be used for researching AIDS.

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Synonyms	HIV-1 inhibitor-25\|CHEMBL4783133\|BDBM50565312\|HY-146019A\|CS-0494940
Molecular Weight	433.46
Molecular Formula	C26H19N5O2
Canonical SMILES	COC1=C(C=CC(=C1)C2=CC=C(C=C2)C#N)C(C3=NC(=NC=C3)NC4=CC=C(C=C4)C#N)O
Purity	≥98% (HPLC)
Solubility	10 mM in DMSO
Appearance	Solid powder
Storage	Store at -20°C
Complexity	713
Exact Mass	433.15387487
Target	HIV (IIIB):13.6 nM (EC50) HIV-1 (L100I):1.2458 ± 0 μM (EC50) HIV-1 (K103N):0.4383 ± 0 μM (EC50) HIV-1 (Y181C):0.5075 ± 0 μM (EC50) HIV-1 (Y188L):5.8136 ± 2 μM (EC50) HIV-1 (E138K):0.1961 ± 0 μM (EC50) HIV-1 (F227L+V106A):3.0683 ± 0 μM (EC50)
XLogP3-AA	4