HIV-1-inhibitor-24

Category	Human immunodeficiency Virus (HIV)
CAS	2475658-75-2
Description	HIV-1 inhibitor-24 (compound S-12a) is a highly potent HIV-1 reverse transcriptase, with an IC50 value of 9.5 nM. HIV-1 inhibitor-24 has high antiretroviral activity against WT HIV-1 with an EC50 of 1.6 nM, and exhibits relatively low cytotoxicity with a CC50 of 9.07 μM in MT-4 cells. HIV-1 inhibitor-24 is well tolerated at a dose of 2 g/kg in mice and has a significant cardiovascular safety.

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Synonyms	HIV-1 inhibitor-24\|CHEMBL4791419\|BDBM50565313\|HY-146019\|CS-0494728
Molecular Weight	433.46
Molecular Formula	C26H19N5O2
Canonical SMILES	COC1=C(C=CC(=C1)C2=CC=C(C=C2)C#N)C(C3=NC(=NC=C3)NC4=CC=C(C=C4)C#N)O
Purity	≥98% (HPLC)
Solubility	10 mM in DMSO
Appearance	Solid powder
Storage	Store at -20°C
Complexity	713
Exact Mass	433.15387487
In Vivo	HIV-1 inhibitor-24 (2 g/kg; IG; single dosage) is well tolerated at a dose of 2 g/kg in mice and has a significant cardiovascular safety. Animal Model: Mice Dosage: 2 g/kg Administration: IG; single dosage Result: Exhibited well tolerance at a dose of 2 g/kg in mice and a significant cardiovascular safety.
Target	HIV-1 (WT):1.6 nM (EC50)
XLogP3-AA	4