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Antiviral API
- Arenavirus
- Cytomegalovirus (CMV)
- Dengue virus
- Endogenous Metabolite
- Enterovirus (EV)
- Epstein-Barr virus (EBV)
- Filovirus
- Flavivirus
- HCV Protease
- Hepatitis B Virus (HBV)
- Hepatitis C Virus (HCV)
- Herpes simplex Virus (HSV)
- HIF/HIF Prolyl-Hydroxylase
- HIV Integrase
- HIV Protease
- Human immunodeficiency Virus (HIV)
- Human papillomavirus (HPV)
- Influenza Virus
- Nipah virus
- Orthopoxvirus
- Others
- Rabies virus (RABV)
- Respiratory syncytial Virus (RSV)
- Reverse Transcriptases (RTs)
- SARS-CoV
- Tobacco mosaic virus (TMV)
- Vesicular stomatitis virus (VSV)
- Virus Protease
- West Nile virus
- Antiviral intermediates
HIV-1-inhibitor-23
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| Category | Human immunodeficiency Virus (HIV) |
| CAS | 2554622-28-3 |
| Description | HIV-1 inhibitor-23 (compound 12a) is a highly potent HIV-1 non-nucleoside reverse transcriptase inhibitor, with EC50s of 24.9 nM and 10.4 nM for HIV-1 WT and HIV-1 K103N, respectively. HIV-1 inhibitor-23 has low cytotoxicity (CC50 > 221 μM) and a favorable in vitro microsomal stability. |
Product Information
| Synonyms | HIV-1 inhibitor-23|CHEMBL4463378|BDBM50504890|HY-146018|CS-0494229|N-(4-cyanophenyl)-2-[4-[4-[(E)-2-cyanovinyl]-2,6-dimethyl-anilino]-6,7-dimethoxy-quinazolin-2-yl]sulfinyl-acetamide |
| Molecular Weight | 566.63 |
| Molecular Formula | C30H26N6O4S |
| Canonical SMILES | CC1=CC(=CC(=C1NC2=NC(=NC3=CC(=C(C=C32)OC)OC)S(=O)CC(=O)NC4=CC=C(C=C4)C#N)C)C=CC#N |
| Purity | ≥98% (HPLC) |
| Solubility | 10 mM in DMSO |
| Appearance | Solid powder |
| Storage | Store at -20°C |
| Complexity | 1030 |
| Exact Mass | 566.17362451 |
| Target | HIV-1 (WT):24.9 μM (EC50) HIV-1 (K103N)10.4 μM (EC50) |
| XLogP3-AA | 5 |