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Antiviral API
- Arenavirus
- Cytomegalovirus (CMV)
- Endogenous Metabolite
- Enterovirus (EV)
- Epstein-Barr virus (EBV)
- Filovirus
- HCV Protease
- Hepatitis B Virus (HBV)
- Hepatitis C Virus (HCV)
- Herpes simplex Virus (HSV)
- HIF/HIF Prolyl-Hydroxylase
- HIV Integrase
- HIV Protease
- Human immunodeficiency Virus (HIV)
- Human papillomavirus (HPV)
- Influenza Virus
- Orthopoxvirus
- Others
- Respiratory syncytial Virus (RSV)
- Reverse Transcriptases (RTs)
- SARS-CoV
- Virus Protease
- Antiviral intermediates
HIV-1-inhibitor-22
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| Category | Human immunodeficiency Virus (HIV) |
| CAS | 2554618-33-4 |
| Description | HIV-1 inhibitor-22 (compound 11a) is a potent HIV-1 non-nucleoside reverse transcriptase (RT) inhibitor, with an IC50 value of 3.63 μM for HIV-1 RT. HIV-1 inhibitor-22 has antiretroviral activity against HIV-1 WT and K103N strains with EC50s of 0.304 M and 0.201 μM, also has low cytotoxicity (CC50 > 227 μM). |
Product Information
| Synonyms | HIV-1 inhibitor-22|CHEMBL4461792|BDBM50504891|HY-146017|CS-0494062|N-(4-cyanophenyl)-2-[4-[4-[(E)-2-cyanovinyl]-2,6-dimethyl-anilino]-6,7-dimethoxy-quinazolin-2-yl]sulfanyl-acetamide |
| Molecular Weight | 550.63 |
| Molecular Formula | C30H26N6O3S |
| Canonical SMILES | CC1=CC(=CC(=C1NC2=NC(=NC3=CC(=C(C=C32)OC)OC)SCC(=O)NC4=CC=C(C=C4)C#N)C)C=CC#N |
| Purity | ≥98% (HPLC) |
| Solubility | 10 mM in DMSO |
| Appearance | Solid powder |
| Storage | Store at -20°C |
| Complexity | 957 |
| Exact Mass | 550.17870989 |
| Target | HIV-1 (WT):0.304 μM (EC50) HIV-1 (K103N):0.201 μM (EC50) |
| XLogP3-AA | 5.7 |
