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Antiviral API
- Arenavirus
- Cytomegalovirus (CMV)
- Endogenous Metabolite
- Enterovirus (EV)
- Epstein-Barr virus (EBV)
- Filovirus
- HCV Protease
- Hepatitis B Virus (HBV)
- Hepatitis C Virus (HCV)
- Herpes simplex Virus (HSV)
- HIF/HIF Prolyl-Hydroxylase
- HIV Integrase
- HIV Protease
- Human immunodeficiency Virus (HIV)
- Human papillomavirus (HPV)
- Influenza Virus
- Orthopoxvirus
- Others
- Respiratory syncytial Virus (RSV)
- Reverse Transcriptases (RTs)
- SARS-CoV
- Virus Protease
- Antiviral intermediates
HIV-1-inhibitor-16
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| Category | Human immunodeficiency Virus (HIV) |
| CAS | 2719675-72-4 |
| Description | HIV-1 inhibitor-16 (compound 7a) is a highly potent HIV-1 inhibitor with an EC50 value of 1.3 nM for HIV-1 WT. HIV-1 inhibitor-16 also has certain inhibitory activity against HIV-1 K103N, E138K, Y181C and L100I strains with EC50s of 5.4 nM, 9.2 nM, 22 nM and 35 nM. HIV-1 inhibitor-16 has favorable solubility and liver microsome stability, and does not exhibit apparent CYP enzymatic inhibitory activity or acute toxicity. |
Product Information
| Synonyms | HIV-1 inhibitor-16|HY-144123|CS-0376707 |
| Molecular Weight | 414.41 |
| Molecular Formula | C23H16F2N6 |
| Canonical SMILES | CC1=CN=C(N=C1NC2=C(C=C(C=C2F)C3=CC=NC=C3)F)NC4=CC=C(C=C4)C#N |
| Purity | ≥98% (HPLC) |
| Solubility | 10 mM in DMSO |
| Appearance | Solid powder |
| Storage | Store at -20°C |
| Complexity | 600 |
| Exact Mass | 414.14045086 |
| Target | HIV-1 (WT):1.3 nM (EC50) HIV-1 (K103N):5.4 nM (EC50) HIV-1 (E138K):9.2 nM (EC50) HIV-1 (Y181C):22 nM (EC50) HIV-1 (L100I):35 mM (EC50) |
| XLogP3-AA | 4.8 |
