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Antiviral API
- Arenavirus
- Cytomegalovirus (CMV)
- Endogenous Metabolite
- Enterovirus (EV)
- Epstein-Barr virus (EBV)
- Filovirus
- HCV Protease
- Hepatitis B Virus (HBV)
- Hepatitis C Virus (HCV)
- Herpes simplex Virus (HSV)
- HIF/HIF Prolyl-Hydroxylase
- HIV Integrase
- HIV Protease
- Human immunodeficiency Virus (HIV)
- Human papillomavirus (HPV)
- Influenza Virus
- Orthopoxvirus
- Others
- Respiratory syncytial Virus (RSV)
- Reverse Transcriptases (RTs)
- SARS-CoV
- Virus Protease
- Antiviral intermediates
HIV-1-inhibitor-15
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| Category | Human immunodeficiency Virus (HIV) |
| CAS | 2757182-99-1 |
| Description | HIV-1 inhibitor-15 (compound 9d) is a highly potent and broad-spectrum HIV-1 inhibitor. HIV-1 inhibitor-15 has inhibitory activity against HIV-1 WT, L100I, K103N, Y181C, E138K with EC50s of 1.7 nM, 4 nM, 2 nM, 6 nM and 9 nM, respectively. HIV-1 inhibitor-15 has good solubility, safety profiles and favorable oral bioavailability. |
Product Information
| Synonyms | HIV-1 inhibitor-15|HIV-1 inhibitor 9d|HIV1-IN-9d|GLXC-25226|HY-144122|CS-0376706|4-((4-((2,6-Dimethyl-4-(pyridin-4-yl)phenyl)amino)pyrimidin-2-yl)amino)benzonitrile |
| Molecular Weight | 392.46 |
| Molecular Formula | C24H20N6 |
| Canonical SMILES | CC1=CC(=CC(=C1NC2=NC(=NC=C2)NC3=CC=C(C=C3)C#N)C)C4=CC=NC=C4 |
| Purity | ≥98% (HPLC) |
| Solubility | 10 mM in DMSO |
| Appearance | Solid powder |
| Storage | Store at -20°C |
| Complexity | 562 |
| Exact Mass | 392.17494466 |
| Target | HIV-1 (WT): 1.7 nM (EC50) HIV-1 (K103N): 4 nM (EC50) HIV-1 (E138K): 2 nM (EC50) HIV-1 (Y181C): 6 nM (EC50) HIV-1 (L100I):9 nM (EC50) |
| XLogP3-AA | 5 |
