HIV-1-inhibitor-15

Category	Human immunodeficiency Virus (HIV)
CAS	2757182-99-1
Description	HIV-1 inhibitor-15 (compound 9d) is a highly potent and broad-spectrum HIV-1 inhibitor. HIV-1 inhibitor-15 has inhibitory activity against HIV-1 WT, L100I, K103N, Y181C, E138K with EC50s of 1.7 nM, 4 nM, 2 nM, 6 nM and 9 nM, respectively. HIV-1 inhibitor-15 has good solubility, safety profiles and favorable oral bioavailability.

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Synonyms	HIV-1 inhibitor-15\|HIV-1 inhibitor 9d\|HIV1-IN-9d\|GLXC-25226\|HY-144122\|CS-0376706\|4-((4-((2,6-Dimethyl-4-(pyridin-4-yl)phenyl)amino)pyrimidin-2-yl)amino)benzonitrile
Molecular Weight	392.46
Molecular Formula	C24H20N6
Canonical SMILES	CC1=CC(=CC(=C1NC2=NC(=NC=C2)NC3=CC=C(C=C3)C#N)C)C4=CC=NC=C4
Purity	≥98% (HPLC)
Solubility	10 mM in DMSO
Appearance	Solid powder
Storage	Store at -20°C
Complexity	562
Exact Mass	392.17494466
Target	HIV-1 (WT): 1.7 nM (EC50) HIV-1 (K103N): 4 nM (EC50) HIV-1 (E138K): 2 nM (EC50) HIV-1 (Y181C): 6 nM (EC50) HIV-1 (L100I):9 nM (EC50)
XLogP3-AA	5