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Antiviral API
- Arenavirus
- Cytomegalovirus (CMV)
- Dengue virus
- Endogenous Metabolite
- Enterovirus (EV)
- Epstein-Barr virus (EBV)
- Filovirus
- Flavivirus
- HCV Protease
- Hepatitis B Virus (HBV)
- Hepatitis C Virus (HCV)
- Herpes simplex Virus (HSV)
- HIF/HIF Prolyl-Hydroxylase
- HIV Integrase
- HIV Protease
- Human immunodeficiency Virus (HIV)
- Human papillomavirus (HPV)
- Influenza Virus
- Nipah virus
- Orthopoxvirus
- Others
- Rabies virus (RABV)
- Respiratory syncytial Virus (RSV)
- Reverse Transcriptases (RTs)
- SARS-CoV
- Tobacco mosaic virus (TMV)
- Vesicular stomatitis virus (VSV)
- Virus Protease
- West Nile virus
- Antiviral intermediates
HIV-1-inhibitor-14
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| Category | Human immunodeficiency Virus (HIV) |
| Description | HIV-1 inhibitor-14 (compound 14b) is a highly potent and broad-spectrum HIV-1 non-nucleoside reverse transcriptase (RT) inhibitor with an EC50 of 0.14 μM for HIV-1 RT. HIV-1 inhibitor-14 has inhibitory activity against HIV-1 WT and resistant strains with EC50s of 5.79 ~ 28.3 nM. |
Product Information
| Synonyms | HIV-1 inhibitor-14|HY-144113|CS-0376556 |
| Molecular Weight | 560.67 |
| Molecular Formula | C29H32N6O4S |
| Canonical SMILES | CC1=CC(=CC(=C1OC2=NC(=NC3=C2COC3)NC4CCN(CC4)C5=CC=C(C=C5)NS(=O)(=O)C)C)C=CC#N |
| Purity | ≥98% (HPLC) |
| Solubility | 10 mM in DMSO |
| Appearance | Solid powder |
| Storage | Store at -20°C |
| Complexity | 999 |
| Exact Mass | 560.22057470 |
| Target | HIV-1 (WT): 6.17 nM (EC50) HIV-1 (L100I): 12.4 nM (EC50) HIV-1 (K103N): 6.91 nM (EC50) HIV-1 (Y181C): 8.91 nM (EC50) HIV-1 (Y188L): 7.66 nM (EC50) HIV-1 (F227L+V106A): 5.79 nM (EC50) HIV-1 (K103N+Y181C): 27.9 nM (EC50) HIV-1 (E138K): 7.66 nM (EC50) |
| XLogP3-AA | 3.9 |