HIV-1-inhibitor-13

Category	Human immunodeficiency Virus (HIV)
Description	HIV-1 inhibitor-13 (compound 16c) is a orally active and potent HIV-1 non nucleoside reverse transcriptase inhibitor (NNRTI), with IC50 of 0.14 μM (HIV-1 RT). HIV-1 inhibitor-13 shows activity against a panel of HIV-1 resistant strains, with EC50 values of 2.85-18.0 nM.

Quotation Now

Synonyms	HIV-1 inhibitor-13\|HY-144112\|CS-0376554
Molecular Weight	524.61
Molecular Formula	C30H32N6O3
Canonical SMILES	CC1=CC(=CC(=C1OC2=NC(=NC3=C2COC3)NC4CCN(CC4)CC5=CC=C(C=C5)C(=O)N)C)C=CC#N
Purity	≥98% (HPLC)
Solubility	10 mM in DMSO
Appearance	Solid powder
Storage	Store at -20°C
Complexity	878
Exact Mass	524.25358890
In Vivo	HIV-1 inhibitor-13 (compound 16c) (SD rats; 2 mg/kg, IV; 10 mg/kg, PO; once) exhibits favorable pharmacokinetic profiles (F = 32.1% and T1/2 = 0.88 and 1.05 h, respectively). HIV-1 inhibitor-13 (Kunming mice, 2000 mg/kg, PO, once) shows safety in Kunming mice (LD50 > 2000 mg/kg).
Target	HIV-1 (WT): 2.85 ± 1.1 nM (EC50)
XLogP3-AA	3.5