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Antiviral API
- Arenavirus
- Cytomegalovirus (CMV)
- Dengue virus
- Endogenous Metabolite
- Enterovirus (EV)
- Epstein-Barr virus (EBV)
- Filovirus
- Flavivirus
- HCV Protease
- Hepatitis B Virus (HBV)
- Hepatitis C Virus (HCV)
- Herpes simplex Virus (HSV)
- HIF/HIF Prolyl-Hydroxylase
- HIV Integrase
- HIV Protease
- Human immunodeficiency Virus (HIV)
- Human papillomavirus (HPV)
- Influenza Virus
- Nipah virus
- Orthopoxvirus
- Others
- Rabies virus (RABV)
- Respiratory syncytial Virus (RSV)
- Reverse Transcriptases (RTs)
- SARS-CoV
- Tobacco mosaic virus (TMV)
- Vesicular stomatitis virus (VSV)
- Virus Protease
- West Nile virus
- Antiviral intermediates
hDHODH-IN-4
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| Category | Influenza Virus |
| CAS | 1644156-56-8 |
| Description | hDHODH-IN-4 is a potent inhibitor of human dihydroorotate dehydrogenase (DHODH), with a pIC50 of 7.8 for human recombinant DHODH. It inhibits measles virus replication, with a pMIC50 of 8.8. |
Product Information
| Synonyms | [1-(5-Cyclopropyl-2-pyrimidinyl)-3-isopropoxy-5-methyl-1H-pyrazol-4-yl](phenyl)methanol; 1H-Pyrazole-4-methanol, 1-(5-cyclopropyl-2-pyrimidinyl)-5-methyl-3-(1-methylethoxy)-α-phenyl-; DHODH-IN-5 |
| IUPAC Name | [1-(5-cyclopropylpyrimidin-2-yl)-5-methyl-3-propan-2-yloxypyrazol-4-yl]-phenylmethanol |
| Molecular Weight | 364.44 |
| Molecular Formula | C21H24N4O2 |
| Canonical SMILES | CC1=C(C(=NN1C2=NC=C(C=N2)C3CC3)OC(C)C)C(C4=CC=CC=C4)O |
| InChI | InChI=1S/C21H24N4O2/c1-13(2)27-20-18(19(26)16-7-5-4-6-8-16)14(3)25(24-20)21-22-11-17(12-23-21)15-9-10-15/h4-8,11-13,15,19,26H,9-10H2,1-3H3 |
| InChIKey | BSNKBAPMWCMENP-UHFFFAOYSA-N |
| Boiling Point | 611.5±65.0°C at 760 mmHg |
| Purity | ≥95% |
| Density | 1.3±0.1 g/cm3 |
| Solubility | Soluble in DMSO |
| Appearance | White to Off-white Solid |
| Storage | Store at 2-8°C |
| Complexity | 473 |
| Exact Mass | 364.18992602 |
| Target | Dihydroorotate Dehydrogenase; DNA/RNA Synthesis; Influenza Virus |
| XLogP3-AA | 3.7 |
