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Antiviral API
- Arenavirus
- Cytomegalovirus (CMV)
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- Endogenous Metabolite
- Enterovirus (EV)
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- HIV Protease
- Human immunodeficiency Virus (HIV)
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- Rabies virus (RABV)
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- Reverse Transcriptases (RTs)
- SARS-CoV
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- Virus Protease
- West Nile virus
- Antiviral intermediates
hDHODH-IN-3
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| Category | Influenza Virus |
| CAS | 1644156-80-8 |
| Description | hDHODH-IN-3, a human dihydroorotate dehydrogenase inhibitor, inhibits measles virus replication with a pMIC50 of 8.6. |
Product Information
| Synonyms | DHODH-IN-2; 2-[4-(2-Bromophenoxy)-3-ethoxy-5-methyl-1H-pyrazol-1-yl]-5-ethylpyrimidine; Pyrimidine, 2-[4-(2-bromophenoxy)-3-ethoxy-5-methyl-1H-pyrazol-1-yl]-5-ethyl- |
| IUPAC Name | 2-[4-(2-bromophenoxy)-3-ethoxy-5-methylpyrazol-1-yl]-5-ethylpyrimidine |
| Molecular Weight | 403.27 |
| Molecular Formula | C18H19BrN4O2 |
| Canonical SMILES | CCC1=CN=C(N=C1)N2C(=C(C(=N2)OCC)OC3=CC=CC=C3Br)C |
| InChI | InChI=1S/C18H19BrN4O2/c1-4-13-10-20-18(21-11-13)23-12(3)16(17(22-23)24-5-2)25-15-9-7-6-8-14(15)19/h6-11H,4-5H2,1-3H3 |
| InChIKey | SNDPFEDGFPXNIX-UHFFFAOYSA-N |
| Boiling Point | 528.9±60.0°C at 760 mmHg |
| Purity | ≥95% |
| Density | 1.4±0.1 g/cm3 |
| Solubility | Soluble in DMSO |
| Appearance | White to off-white (Solid) |
| Storage | Store at -20°C |
| Complexity | 409 |
| Exact Mass | 402.06914 |
| In Vitro | In self-organizing molecular field analysis (SOMFA), hDHODH-IN-2 (compound 42) had log 1/IC50s of 5.83 and 5.80 for DODH in rats and mice, respectively. |
| Target | Dihydroorotate Dehydrogenase; DNA/RNA Synthesis; Influenza Virus |
| XLogP3-AA | 4.6 |
