HBV-IN-20

Category	Hepatitis B Virus (HBV)
CAS	2750254-34-1
Description	HBV-IN-20 is a potent and oral active HBV inhibitor with an EC50 of 0.46 µM. HBV-IN-20 is a typical type II CpAM (core protein assembly modulators).

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Synonyms	HBV-IN-20\|HY-145872\|CS-0434324
Molecular Weight	324.78
Molecular Formula	C16H18ClFN2O2
Canonical SMILES	C1CCC2C(C1)C(=O)CCN2C(=O)NC3=CC(=C(C=C3)F)Cl
Purity	≥98% (HPLC)
Solubility	10 mM in DMSO
Appearance	Solid powder
Storage	Store at -20°C
Complexity	448
Exact Mass	324.1040837
In Vitro	HBV-IN-20 (compound 61) (5 µM; 6 days) is a typical type II CpAM (core protein assembly modula tors). Western Blot Analysis.
In Vivo	HBV-IN-20 (3 mg/kg for i.v.; 10 mg/kg for p.o.) shows 69% of oral bioavailability. Pharmacokinetic Parameters of HBV-IN-20 in mouse.
Target	EC50: 0.46 µM (HBV)
XLogP3-AA	2.8