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Antiviral API
- Arenavirus
- Cytomegalovirus (CMV)
- Dengue virus
- Endogenous Metabolite
- Enterovirus (EV)
- Epstein-Barr virus (EBV)
- Filovirus
- Flavivirus
- HCV Protease
- Hepatitis B Virus (HBV)
- Hepatitis C Virus (HCV)
- Herpes simplex Virus (HSV)
- HIF/HIF Prolyl-Hydroxylase
- HIV Integrase
- HIV Protease
- Human immunodeficiency Virus (HIV)
- Human papillomavirus (HPV)
- Influenza Virus
- Nipah virus
- Orthopoxvirus
- Others
- Rabies virus (RABV)
- Respiratory syncytial Virus (RSV)
- Reverse Transcriptases (RTs)
- SARS-CoV
- Tobacco mosaic virus (TMV)
- Vesicular stomatitis virus (VSV)
- Virus Protease
- West Nile virus
- Antiviral intermediates
GS-9822
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| Category | Human immunodeficiency Virus (HIV) |
| CAS | 2219362-41-9 |
| Description | GS-9822 is one of novel non-catalytic site integrase inhibitors (NCINIs), which is a potential class of antiretroviral (ARV) agents. GS-9822 exhibits a potent effect against the T174I mutant (EC50: 3.0 ± 0.9 nM) and IN polymorphic variants (fold shift: 0.4 to 1.3). Studies showed that it has excellent pharmacokinetic properties and metabolic stability. |
Product Information
| Synonyms | 2219362-41-9;GS-9822;(S)-2-(tert-Butoxy)-2-(7-(4-chlorophenyl)-5-methyl-2-(1-methyl-3-(1-(oxetan-3-yl)piperidin-4-yl)-1H-indazol-5-yl)benzo[d]thiazol-6-yl)acetic acid;SCHEMBL20030699;DA-63908;HY-122229;CS-0082907;(2S)-2-tert-butoxy-2-[7-(4-chlorophenyl)-5-methyl-2-[1-methyl-3-[1-(oxetan-3-yl)-4-piperidyl]indazol-5-yl]-1,3-benzothiazol-6-yl]acetic acid; |
| IUPAC Name | (2S)-2-[7-(4-chlorophenyl)-5-methyl-2-[1-methyl-3-[1-(oxetan-3-yl)piperidin-4-yl]indazol-5-yl]-1,3-benzothiazol-6-yl]-2-[(2-methylpropan-2-yl)oxy]acetic acid |
| Molecular Weight | 251.24 |
| Molecular Formula | C10H13N5O3 |
| Canonical SMILES | C1[C@H]([C@@H]([C@@H]([C@H]1O)O)O)N2C=NC3=C(N=CN=C32)N |
| InChI | InChI=1S/C36H39ClN4O4S/c1-20-16-27-33(30(21-6-9-24(37)10-7-21)29(20)32(35(42)43)45-36(2,3)4)46-34(38-27)23-8-11-28-26(17-23)31(39-40(28)5)22-12-14-41(15-13-22)25-18-44-19-25/h6-11,16-17,22,25,32H,12-15,18-19H2,1-5H3,(H,42,43)/t32-/m0/s1 |
| InChIKey | RRMWWVMCCINVHZ-YTTGMZPUSA-N |
| Application | antiretroviral (ARV) agent |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
