GRL-0496

Category	SARS-CoV
CAS	1087243-14-8
Description	GRL-0496 is a potent chloropyridyl ester-derived SARS-CoV 3CLpro inhibitor, with an IC50 of 30 nM in both enzyme inhibitory and antiviral assays. GRL-0496 shows SARS-CoV antiviral activity, with an EC50 of 6.9 μM.

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Synonyms	GRL-0496\|(5-chloropyridin-3-yl) 1H-indole-4-carboxylate\|CHEMBL490820\|SCHEMBL22875686\|GTPL11173\|jm5b01461, Compound 124\|ALP-POS-c59291d4-5\|GRL0496\|CHEBI:149970\|BDBM429304\|compound 10 [PMID:18796354]\|1087243-14-8\|HY-137954\|CS-0143213\|5-chloropyridin-3-yl 1H-indole-4-carboxylate
Molecular Weight	272.69
Molecular Formula	C14H9ClN2O2
Canonical SMILES	C1=CC(=C2C=CNC2=C1)C(=O)OC3=CC(=CN=C3)Cl
Purity	≥98% (HPLC)
Solubility	In Vitro: DMSO : 100 mg/mL(366.72 mM;Need ultrasonic) In Vivo: 1.Add each solvent one by one:10% DMSO >> 40%PEG300 >> 5%Tween-80 >> 45% saline Solubility: ≥ 2.5 mg/mL (9.17 mM); Clear solution 2.Add each solvent one by one:10% DMSO >> 90% (20%SBE-β-CDin saline) Solubility: ≥ 2.5 mg/mL (9.17 mM); Clear solution 3.Add each solvent one by one:10% DMSO >> 90%corn oil Solubility: ≥ 2.5 mg/mL (9.17 mM); Clear solution
Appearance	Light yellow to green yellow (Solid)
Storage	Powder: -20°C: 3 years 4°C: 2 years In solvent: -80°C: 6 months -20°C: 1 month
Complexity	339
Exact Mass	272.0352552
In Vitro	GRL-0496 shows SARS-CoV antiviral activity, with an EC50 of 6.9 μM.
Target	IC50: 30 nM (SARS-CoV 3CLpro)
XLogP3-AA	2.8