gp120-IN-1

Category	Human immunodeficiency Virus (HIV)
CAS	5948-75-4
Description	gp120-IN-1 (compound 4e) is a potent HIV-1 gp120 inhibitor with an IC50 of 2.2 µM and CC50 of 100.90 µM. gp120-IN-1 shows anti-HIV-1 activity. gp120-IN-1 shows cytotoxicity in a dose dependent manner in SUP-T1 cells. gp120-IN-1 shows inhibition of gp120-mediated virus enter into cells.

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Synonyms	5948-75-4\|gp120-IN-1\|ETHYL 4-(4-HYDROXY-3-METHOXYPHENYL)-6-METHYL-2-SULFANYL-1,4-DIHYDROPYRIMIDINE-5-CARBOXYLATE\|ethyl 4-(4-hydroxy-3-methoxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate\|Oprea1_375453\|CHEMBL2013079\|SCHEMBL13419868\|MFCD03804675\|STK802514\|ZINC00190545\|AKOS000653308\|AKOS002237797\|AKOS002353682\|AKOS016045142\|AKOS016088640\|AKOS016293158\|UPCMLD0ENAT5762053:001\|ethyl 4-(4-hydroxy-3-methoxyphenyl)-6-methyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxylate\|HY-144730\|CS-0434381\|SR-01000403136\|SR-01000488652\|SR-01000403136-1\|SR-01000488652-1\|F0896-0356\|ethyl 4-(4-hydroxy-3-methoxyphenyl)-2-mercapto-6-methyl-1,4-dihydropyrimidine-5-carboxylate\|ethyl 4-(4-hydroxy-3-methoxyphenyl)-6-methyl-2-sulfanyl-1,4-dihydro-5-pyrimidinecarboxylate\|ethyl 6-(4-hydroxy-3-methoxyphenyl)-2-mercapto-4-methyl-1,6-dihydro-5-pyrimidinecarboxylate
Molecular Weight	322.38
Molecular Formula	C15H18N2O4S
Canonical SMILES	CCOC(=O)C1=C(NC(=S)NC1C2=CC(=C(C=C2)O)OC)C
Purity	≥98% (HPLC)
Solubility	10 mM in DMSO
Appearance	Solid powder
Storage	Store at -20°C
Complexity	480
Exact Mass	322.09872823
Target	HIV
XLogP3-AA	1.6