-
Antiviral API
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Golgicide A
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| Category | Enterovirus (EV) |
| CAS | 1139889-93-2 |
| Description | Golgicide A causes a decrease in GBF1-mediated Arf1 activation, arrests secretion of soluble and membrane-anchored proteins and then impairs retrograde toxin transport. |
Product Information
| Synonyms | GCA; (3aR,9bS)-rel-6,8-Difluoro-3a,4,5,9b-tetrahydro-4-(3-pyridinyl)-3H-cyclopenta[c]quinoline; 3H-Cyclopenta[c]quinoline, 6,8-difluoro-3a,4,5,9b-tetrahydro-4-(3-pyridinyl)-, (3aR,9bS)- |
| IUPAC Name | (3aR,9bS)-6,8-difluoro-4-pyridin-3-yl-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline |
| Molecular Weight | 284.30 |
| Molecular Formula | C17H14F2N2 |
| Canonical SMILES | C1C=CC2C1C(NC3=C(C=C(C=C23)F)F)C4=CN=CC=C4 |
| InChI | InChI=1S/C17H14F2N2/c18-11-7-14-12-4-1-5-13(12)16(10-3-2-6-20-9-10)21-17(14)15(19)8-11/h1-4,6-9,12-13,16,21H,5H2/t12-,13+,16?/m0/s1 |
| InChIKey | NJZHEQOUHLZCOX-FTLRAWMYSA-N |
| Boiling Point | 383.0±42.0°C at 760 mmHg |
| Flash Point | 379.9°C |
| Purity | >98% |
| Density | 1.3±0.1 g/cm3 |
| Solubility | Soluble in DMSO |
| Appearance | Off-white Solid |
| Storage | -20 °C |
| Complexity | 414 |
| Exact Mass | 284.11250478 |
| Index Of Refraction | 1.662 |
| In Vitro | Golgicide A (GCA) is a potent and highly effective inhibitor of shiga toxin activity. Golgicide A (GCA) inhibits the effect of shiga toxin on protein synthesis with an IC50 of 3.3 μM. |
| PSA | 65.20000 |
| Target | Enterovirus: GBF1 |
| XLogP3-AA | 3.5 |
