Golgicide A-2

Category	Enterovirus (EV)
CAS	1394285-50-7
Description	Golgicide A-2, a Golgicide A (GCA) derivative, is the most active stereoisomer of golgicide A. Golgicide A-2 is a cis-Golgi ArfGEF GBF inhibitor with high selectivity and efficiency in killing An. stephensi larvae. It can be used for research on dengue virus-related diseases.

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Synonyms	GCA-2; 3H-Cyclopenta[c]quinoline, 6,8-difluoro-3a,4,5,9b-tetrahydro-4-(3-pyridinyl)-, (3aS,4R,9bR)-; (3aS,4R,9bR)-golgicide A; (3aS,4R,9bR)-6,8-Difluoro-4-(3-pyridinyl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline
IUPAC Name	(3aS,4R,9bR)-6,8-difluoro-4-pyridin-3-yl-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline
Molecular Weight	284.30
Molecular Formula	C17H14F2N2
Canonical SMILES	C1C=CC2C1C(NC3=C2C=C(C=C3F)F)C4=CN=CC=C4
InChI	InChI=1S/C17H14F2N2/c18-11-7-14-12-4-1-5-13(12)16(10-3-2-6-20-9-10)21-17(14)15(19)8-11/h1-4,6-9,12-13,16,21H,5H2/t12-,13+,16+/m1/s1
InChIKey	NJZHEQOUHLZCOX-WWGRRREGSA-N
Boiling Point	383.0±42.0°C at 760 mmHg
Purity	≥95%
Density	1.3±0.1 g/cm3
Solubility	Soluble in DMSO
Appearance	White to light brown (Solid)
Storage	Store at -20°C
Complexity	414
Exact Mass	284.11250478
In Vitro	GCA-2 is effective in killing both Ae. Aegypti and An. Stephensi larvae, while it is displays distinct and strongly selective cytotoxicity towards Ae. Stephensi larvae with a mortality of 83.4%.
Target	Enterovirus
XLogP3-AA	3.5