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Antiviral API
- Arenavirus
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- Endogenous Metabolite
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Glaucine-d6
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| Category | Influenza Virus |
| Description | Glaucine-d6 (O,O-Dimethylisoboldine-d6) is the deuterium labeled Glaucine. Glaucine (O,O-Dimethylisoboldine) is an alkaloid isolated from Glaucium flavum Crantz with antitussive, bronchodilation and anti-inflammatory properties. Glaucine is a selective and orally active phosphodiesterase 4 (PDE4) inhibitor with Kis of 3.4 µM in human bronchus and polymorphonuclear leukocytes. Glaucine is also a non-selective α-adrenoceptor antagonist,a Ca2+ entry blocker, and a weak dopamine D1 and D2 receptor antagonist. Glaucine has antioxidative and antiviral activities. |
Product Information
| Synonyms | Glaucine-d6|HY-N3945S|CS-0370323 |
| Molecular Weight | 361.46 |
| Molecular Formula | C21H25NO4 |
| Canonical SMILES | CN1CCC2=CC(=C(C3=C2C1CC4=CC(=C(C=C43)OC)OC)OC)OC |
| Purity | ≥98% (HPLC) |
| Solubility | In vitro: 10 mM in DMSO |
| Appearance | Solid powder |
| Storage | Store at -20°C |
| Complexity | 489 |
| Exact Mass | 361.21601875 |
| In Vitro | Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and Metabolic profiles of drugs. |
| PSA | 137.41000 |
| Target | Phosphodiesterase (PDE); Calcium Channel; Adrenergic Receptor; Dopamine |
| XLogP3-AA | 3.4 |
