-
Antiviral API
- Arenavirus
- Cytomegalovirus (CMV)
- Dengue virus
- Endogenous Metabolite
- Enterovirus (EV)
- Epstein-Barr virus (EBV)
- Filovirus
- Flavivirus
- HCV Protease
- Hepatitis B Virus (HBV)
- Hepatitis C Virus (HCV)
- Herpes simplex Virus (HSV)
- HIF/HIF Prolyl-Hydroxylase
- HIV Integrase
- HIV Protease
- Human immunodeficiency Virus (HIV)
- Human papillomavirus (HPV)
- Influenza Virus
- Nipah virus
- Orthopoxvirus
- Others
- Rabies virus (RABV)
- Respiratory syncytial Virus (RSV)
- Reverse Transcriptases (RTs)
- SARS-CoV
- Tobacco mosaic virus (TMV)
- Vesicular stomatitis virus (VSV)
- Virus Protease
- West Nile virus
- Antiviral intermediates
GCA-186
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| Category | Human immunodeficiency Virus (HIV) |
| CAS | 149950-61-8 |
| Description | GCA-186 is a potent anti-HIV-1 agent. GCA-186 is highly active against both wild type and mutated HIV-1 strains with EC50s of 1,180, 1, and 40 nM for IIIB, IIIB-R(Y181C), NL4-3 and NL4-3K103N of HIV-1 strains, respectively. |
Product Information
| Synonyms | gca-186|I-EBU-dM|6-(3',5'-DIMETHYLBENZYL)-1-ETHOXYMETHYL-5-ISOPROPYLURACIL|CHEMBL319139|CHEBI:42702|6-(3,5-dimethylbenzyl)-1-(ethoxymethyl)-5-isopropyluracil|6-[(3,5-dimethylphenyl)methyl]-1-(ethoxymethyl)-5-propan-2-ylpyrimidine-2,4-dione|149950-61-8|6-(3,5-dimethylbenzyl)-1-(ethoxymethyl)-5-(1-methylethyl)uracil|6-(3,5-dimethylbenzyl)-1-(ethoxymethyl)-5-(1-methylethyl)pyrimidine-2,4(1H,3H)-dione|6-(3,5-dimethylbenzyl)-1-(ethoxymethyl)-5-(propan-2-yl)pyrimidine-2,4(1H,3H)-dione|BDBM50032238|DB07820|HY-116528|CS-0065708|Q27097031|6-(3,5-Dimethylbenzyl)-1-(ethoxymethyl])-5-isopropyluracil|6-(3'',5''-DIMETHYLBENZYL)-1-ETHOXYMETHYL-5-ISOPROPYLURACIL|6-(3,5-Dimethyl-benzyl)-1-ethoxymethyl-5-isopropyl-1H-pyrimidine-2,4-dione|6-[(3,5-dimethylphenyl)methyl]-1-(ethoxymethyl)-5-isopropyl-pyrimidine-2,4-dione |
| Molecular Weight | 330.42 |
| Molecular Formula | C19H26N2O3 |
| Canonical SMILES | CCOCN1C(=C(C(=O)NC1=O)C(C)C)CC2=CC(=CC(=C2)C)C |
| Purity | ≥98% |
| Solubility | In vitro: 10 mM in DMSO |
| Appearance | Solid powder |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -23 C for long term (months to years). |
| Complexity | 503 |
| Exact Mass | 330.19434270 |
| In Vitro | GCA-186 shows antiviral activity (EC50=0.6 nM) and cytotoxicity against HIV-1 in MT-4 cells (CC50=43 μM). |
| Target | HIV |
| XLogP3-AA | 3.3 |
