GC376 sodium

Category	SARS-CoV
CAS	1416992-39-6
Description	GC376 is a 3CLpro inhibitor which is previously reported to be active against the 3CLpro of multiple coronaviruses, including SARS-CoV, but with highest potency against FIPV in cell culture. GC376 inhibits the replication of viruses TGEV, FIPV and PTV with IC50 values of 0.15, 0.2 and 0.15 μM.

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Synonyms	GC376 sodium; GC 376 sodium; GC-376 sodium; (2S)-1-hydroxy-2-[[(2S)-4-methyl-2-(phenylmethoxycarbonylamino)pentanoyl]amino]-3-(2-oxopyrrolidin-3-yl)propane-1-sulfonate sodium
Molecular Weight	507.53
Molecular Formula	C21H30N3NaO8S
Canonical SMILES	CC(C)CC(C(=O)NC(CC1CCNC1=O)C(O)S(=O)(=O)O)NC(=O)OCC2=CC=CC=C2.[Na+]
InChI	InChI=1S/C21H31N3O8S.Na/c1-13(2)10-16(24-21(28)32-12-14-6-4-3-5-7-14)19(26)23-17(20(27)33(29,30)31)11-15-8-9-22-18(15)25;/h3-7,13,15-17,20,27H,8-12H2,1-2H3,(H,22,25)(H,23,26)(H,24,28)(H,29,30,31);/q;+1/t15?,16-,17-,20?;/m0./s1
InChIKey	BSPJDKCMFIPBAW-JPBGFCRCSA-N
Purity	≥98% (HPLC)
Solubility	Soluble in DMSO.
Appearance	Solid powder
Storage	Store in a cool and dry place (or refer to the Certificate of Analysis).
Complexity	783
Exact Mass	507.16513038
Target	SARS-CoV-2