Gardiquimod-diTFA

Category	Human immunodeficiency Virus (HIV)
CAS	1159840-61-5
Description	Gardiquimod diTFA, an imidazoquinoline analog, is a TLR7/8 agonist. Gardiquimod diTFA could inhibit HIV-1 infection of macrophages and activated peripheral blood mononuclear cells (PBMCs). Gardiquimod diTFA specifically activates TLR7 when used at concentrations below 10 μM.

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Synonyms	Gardiquimod (diTFA)\|HY-103697A
Molecular Weight	541.44
Molecular Formula	C21H25F6N5O5
Purity	99.77%
Solubility	In Vitro: DMSO : 50 mg/mL(92.35 mM;Need ultrasonic) H2O : 25 mg/mL(46.17 mM;Need ultrasonic) In Vivo: 1.Add each solvent one by one:PBS Solubility: 50 mg/mL (92.35 mM); Clear solution; Need ultrasonic 2.Add each solvent one by one:10% DMSO >> 40%PEG300 >> 5%Tween-80 >> 45% saline Solubility: ≥ 2.5 mg/mL (4.62 mM); Clear solution 3.Add each solvent one by one:10% DMSO >> 90% (20%SBE-β-CDin saline) Solubility: ≥ 2.5 mg/mL (4.62 mM); Clear solution 4.Add each solvent one by one:10% DMSO >> 90%corn oil Solubility: ≥ 2.5 mg/mL (4.62 mM); Clear solution
Appearance	White to off-white (Solid)
Storage	4°C, sealed storage, away from moisture * In solvent : -80°C, 6 months -20°C, 1 month (sealed storage, away from moisture)
Target	Toll-like Receptor (TLR); HIV