Ganciclovir

Category	Cytomegalovirus (CMV)
CAS	82410-32-0
Description	Ganciclovir is an antiviral drug for feline herpesvirus type-1 with IC50 of 5.2 μM.

Quotation Now

Product Information

Synonyms	Cytovene; BW 759; BW759; BW-759; 2'-Nor-2'-deoxyguanosine
IUPAC Name	2-amino-9-(1,3-dihydroxypropan-2-yloxymethyl)-1H-purin-6-one
Molecular Weight	255.23
Molecular Formula	C9H13N5O4
Canonical SMILES	C1=NC2=C(N1COC(CO)CO)NC(=NC2=O)N
InChI	InChI=1S/C9H13N5O4/c10-9-12-7-6(8(17)13-9)11-3-14(7)4-18-5(1-15)2-16/h3,5,15-16H,1-2,4H2,(H3,10,12,13,17)
InChIKey	IRSCQMHQWWYFCW-UHFFFAOYSA-N
Boiling Point	675°C at 760 mmHg
Melting Point	251-252°C
Purity	>98%
Density	1.81 g/cm3
Solubility	Soluble in DMSO
Appearance	White Solid
Application	Antiviral agents
Storage	Store at -20°C
Animal Admin	Two albino rats non-immunized for MCMV are used in the study. The first rat receives 50 mg/kg of ganciclovir twice a day (i.e. 100 mg/kg/day), for a total of 3 days or 6 injections. The second rat is used as a negative control and received intraperitoneal injections of glucose solution. Ganciclovir is diluted in 5% glucose serum to a concentration of 5 mg/mL and administered intraperitoneally in newborn mice at a dose of 50 mg/kg twice a day. Five injections are administered in total.
Complexity	346
Exact Mass	255.09675391
In Vitro	Ganciclovir also has activity in vitro against members of the herpes group and some other DNA viruses. Ganciclovir inhibits the in vitro replication of human herpes viruses (HSV 1 and 2, CMV) and adenovirus serotypes 1, 2, 4, 6, 8, 10, 19, 22 and 28. Ganciclovir has an IC50 of 5.2 μM for feline herpesvirus type-1 (FHV-1) and can diffuse into the brain.
In Vivo	In adult rats, the intracochlear diffusion of ganciclovir is shown to achieve the same concentration as in blood. In newborn mice, the plasma concentration profile of ganciclovir shows a peak at 2 h followed by a gradual decrease. In adult mice, the concentration peaked at 1 h, but becomes undetectable by 2 h after injection. Counts of white blood cells, red blood cells and platelets decreases significantly in ganciclovir-treated newborn mice.
PSA	53.99000
Target	CMV; HSV; Antibiotic; Nucleoside Antimetabolite/Analog. IC50: 5.2 μM (FHV-1)
XLogP3-AA	-2.5