-
Antiviral API
- Arenavirus
- Cytomegalovirus (CMV)
- Dengue virus
- Endogenous Metabolite
- Enterovirus (EV)
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- Human immunodeficiency Virus (HIV)
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- West Nile virus
- Antiviral intermediates
Fumagillin
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| Category | Human immunodeficiency Virus (HIV) |
| CAS | 23110-15-8 |
| Description | Fumagillin is a compound isolated from the fungus Aspergillus fumigatus. Fumagillin is an antimicrobial agent used in the treatment of microsporidiosis. Fumagillin shows promise as both an anti-infective and antiangiogenic agent. |
Product Information
| Synonyms | NSC-9168; Fumidil B; Fumagillin; Fumagilina; Fugillin; Fumidil |
| IUPAC Name | (2E,4E,6E,8E)-10-[[(3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methylbut-2-enyl)oxiran-2-yl]-1-oxaspiro[2.5]octan-6-yl]oxy]-10-oxodeca-2,4,6,8-tetraenoic acid |
| Molecular Weight | 458.54 |
| Molecular Formula | C26H34O7 |
| Canonical SMILES | CC(=CCC1C(O1)(C)C2C(C(CCC23CO3)OC(=O)C=CC=CC=CC=CC(=O)O)OC)C |
| InChI | InChI=1S/C26H34O7/c1-18(2)13-14-20-25(3,33-20)24-23(30-4)19(15-16-26(24)17-31-26)32-22(29)12-10-8-6-5-7-9-11-21(27)28/h5-13,19-20,23-24H,14-17H2,1-4H3,(H,27,28)/b7-5+,8-6+,11-9+,12-10+/t19-,20-,23-,24-,25+,26+/m1/s1 |
| InChIKey | NGGMYCMLYOUNGM-CSDLUJIJSA-N |
| Boiling Point | 484.03°C at 760 mmHg |
| Melting Point | 189-194°C |
| Flash Point | 198.8°C |
| Purity | >98% |
| Density | 1.1368 g/cm3 |
| Solubility | Soluble in ethanol, methanol, DMF or DMSO. Poor water solubility. |
| Appearance | White to Off-white Solid |
| Storage | -20°C |
| Complexity | 879 |
| Exact Mass | 458.23045342 |
| Index Of Refraction | 1.562 |
| In Vitro | Fumagillin is an active amebicide and anti-infective isolated from the fungus Aspergillus fumigatus. Fumagillin does exhibit some side effects that have deterred its acceptance as a viable treatment, but the current body of research on the synthesis of novel analogs of this molecule shows an exciting and promising revival of this drug as both an anti-infective and antiangiogenic agent. |
| PSA | 97.89000 |
| Target | Parasite; HIV; Antibiotic |
| Vapor Pressure | 2.7E-16mmHg at 25°C |
| XLogP3-AA | 4 |
