-
Antiviral API
- Arenavirus
- Cytomegalovirus (CMV)
- Dengue virus
- Endogenous Metabolite
- Enterovirus (EV)
- Epstein-Barr virus (EBV)
- Filovirus
- Flavivirus
- HCV Protease
- Hepatitis B Virus (HBV)
- Hepatitis C Virus (HCV)
- Herpes simplex Virus (HSV)
- HIF/HIF Prolyl-Hydroxylase
- HIV Integrase
- HIV Protease
- Human immunodeficiency Virus (HIV)
- Human papillomavirus (HPV)
- Influenza Virus
- Nipah virus
- Orthopoxvirus
- Others
- Rabies virus (RABV)
- Respiratory syncytial Virus (RSV)
- Reverse Transcriptases (RTs)
- SARS-CoV
- Tobacco mosaic virus (TMV)
- Vesicular stomatitis virus (VSV)
- Virus Protease
- West Nile virus
- Antiviral intermediates
Foscarnet sodium
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| Category | Human immunodeficiency Virus (HIV) |
| CAS | 63585-09-1 |
| Description | Foscarnet Sodium inhibits viral RNA polymerases, reverse transcriptases and DNA polymerases by non-competitive inhibition of dNTPs. It is an antiviral agent used in the treatment of cytomegalovirus retinitis. It has activity against human herpesviruses and HIV. |
Product Information
| Synonyms | Trisodium phosphonoformate; Trisodium carboxyphosphate; Foscarnet trisodium; Phosphonoformic acid trisodium salt; 1,1-Dihydroxyphosphinecarboxylic Acid 1-Oxide Sodium Salt; A 29622; EHB 776; Gefin; Triapten |
| IUPAC Name | trisodium;phosphonatoformate |
| Molecular Weight | 191.95 |
| Molecular Formula | CNa3O5P |
| Canonical SMILES | C(=O)([O-])P(=O)([O-])[O-].[Na+].[Na+].[Na+] |
| InChI | InChI=1S/CH3O5P.3Na/c2-1(3)7(4,5)6;;;/h(H,2,3)(H2,4,5,6);;;/q;3*+1/p-3 |
| InChIKey | DFHAXXVZCFXGOQ-UHFFFAOYSA-K |
| Boiling Point | 270-272°C |
| Melting Point | >250°C |
| Flash Point | 270-272°C |
| Purity | >98% |
| Solubility | Soluble in Water (Sparingly, Heated) |
| Appearance | White Crystal |
| Application | Antiviral Agents |
| Storage | Store at 2-8°C |
| Complexity | 103 |
| Exact Mass | 191.91764294 |
| In Vitro | Foscarnet sodium (Trisodium phosphonoformate) inhibits Influenza A Victoria (IC50=29 μM), Influenza B HK (IC50=61 μM), and Avian myeloblastosis virus (IC50=5-8 μM), HSV-1, several strains (IC50=0.4-3.5 μM). |
| PSA | 113.13000 |
| Target | Virus Protease; DNA/RNA Synthesis |
