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Antiviral API
- Arenavirus
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- Antiviral intermediates
Formycin A
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| Category | Human immunodeficiency Virus (HIV) |
| CAS | 6742-12-7 |
| Description | Formycin A is produced by the strain of Nocardia intriforma M4-C5. It has the activity of resistance to Salicornia, Pyricularia oryzae and Mole disease Phanerochaetehrysosporium of potato. |
Product Information
| Synonyms | (1S)-1-(7-amino-1H-pyrazolo[4,3-d]pyrimidin-3-yl)-1,4-anhydro-D-ribitol; NSC 102811; BRN 0624229; 7-Amino-3-beta-D-ribofuranosyl-1H-pyrazolo(4,3-d)pyrimidine |
| IUPAC Name | (2S,3R,4S,5R)-2-(7-amino-2H-pyrazolo[4,3-d]pyrimidin-3-yl)-5-(hydroxymethyl)oxolane-3,4-diol |
| Molecular Weight | 267.24 |
| Molecular Formula | C10H13N5O4 |
| Canonical SMILES | C1=NC2=C(NN=C2C(=N1)N)C3C(C(C(O3)CO)O)O |
| InChI | InChI=1S/C10H13N5O4/c11-10-6-4(12-2-13-10)5(14-15-6)9-8(18)7(17)3(1-16)19-9/h2-3,7-9,16-18H,1H2,(H,14,15)(H2,11,12,13)/t3-,7-,8-,9+/m1/s1 |
| InChIKey | KBHMEHLJSZMEMI-KSYZLYKTSA-N |
| Boiling Point | 709.5°C at 760 mmHg |
| Melting Point | 141-142°C |
| Purity | ≥ 97% |
| Density | 1.771 g/cm3 |
| Solubility | In vitro: 10 mM in DMSO |
| Appearance | White Crystalline |
| Application | Antineoplastic Agents |
| Storage | Powder: -20°C: 3 years 4°C: 2 years In solvent: -80°C: 6 months -20°C: 1 month |
| Complexity | 335 |
| Exact Mass | 267.09675391 |
| In Vitro | Formycin A (NSC 102811; 1 μM, 5 μM, 10 μM) antagonizes Zidovudine (AZT; a dideoxynucleoside chain terminator). |
| PSA | 150.40000 |
| Target | HIV; Nucleoside Antimetabolite/Analog; Antibiotic |
| XLogP3-AA | -2.2 |
