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Antiviral API
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EV-A71-IN-1
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| Category | Enterovirus (EV) |
| CAS | 2413648-96-9 |
| Description | EV-A71-IN-1 is a human enterovirus A71 (EV-A71) capsid protein inhibitor with an EC50 of 0.27 μM against EV-A71. EV-A71-IN-1 is a capsid binder that blocks the interaction between the viral VP1 and the host receptor hSCARB2. EV-A71-IN-1 inhibits a series of different human enteroviruses without significant cytotoxicity (CC50>56.2 μM). |
Product Information
| Synonyms | EV-A71-IN-1|HY-145850|CS-0434218 |
| Molecular Weight | 369.44 |
| Molecular Formula | C21H15N5S |
| Canonical SMILES | C1=CC=C(C=C1)C2=CC=C(C=C2)NC3=NC(=CS3)C4=CN=C5N4C=CC=N5 |
| Purity | ≥98% (HPLC) |
| Solubility | In vitro: 10 mM in DMSO |
| Appearance | Solid powder |
| Storage | Store at -20°C |
| Complexity | 477 |
| Exact Mass | 369.10481667 |
| In Vitro | EV-A71-IN-1 (compound 12s) shows activity not only against different EV-A71 strains (BrCr, GZ-CII, EV71/HeN09 and EV71/G082) but also against other representative enteroviruses (CV-A16, EV-D68, Echov-6, CV-B2 and CV-B6). |
| Target | Enterovirus |
| XLogP3-AA | 5.3 |
