Eriodictyol

Category	Endogenous Metabolite
CAS	552-58-9
Description	Eriodictyol is a natural flavonoid found in the fruits of Citrus sinensis (L.) Osbeck. Eriodictyol exhibits activities of antidiabetic, anti-inflammatory and antioxidant. Eriodictyol can increases glucose uptake and improves insulin resistance.

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Product Information

Synonyms	(S)-2-(3,4-dihydroxyphenyl)-2,3-dihydro-5,7-dihydroxy-4-benzopyrone; 2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-2,3-dihydro-4H-chromen-4-one; 3',4',5,7-tetrahydroxyflavanone; 4H-1-benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-2,3-dihydro-5,7-dihydroxy-
IUPAC Name	(2S)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-2,3-dihydrochromen-4-one
Molecular Weight	288.25
Molecular Formula	C15H12O6
Canonical SMILES	C1C(OC2=CC(=CC(=C2C1=O)O)O)C3=CC(=C(C=C3)O)O
InChI	InChI=1S/C15H12O6/c16-8-4-11(19)15-12(20)6-13(21-14(15)5-8)7-1-2-9(17)10(18)3-7/h1-5,13,16-19H,6H2/t13-/m0/s1
InChIKey	SBHXYTNGIZCORC-ZDUSSCGKSA-N
Boiling Point	625.2±55.0 °C at 760 mmHg
Melting Point	270ºC
Flash Point	241.9±25.0 °C
Purity	>97%
Density	1.6±0.1 g/cm3
Solubility	In Vitro: DMSO : 125 mg/mL(433.65 mM;Need ultrasonic) H2O : < 0.1 mg/mL(insoluble) In Vivo: 1.Add each solvent one by one:10% DMSO >> 40%PEG300 >> 5%Tween-80 >> 45% saline Solubility: ≥ 2.58 mg/mL (8.95 mM); Clear solution 2.Add each solvent one by one:10% DMSO >> 90% (20%SBE-β-CDin saline) Solubility: ≥ 2.58 mg/mL (8.95 mM); Clear solution 3.Add each solvent one by one:10% DMSO >> 90%corn oil Solubility: ≥ 2.58 mg/mL (8.95 mM); Clear solution
Appearance	Powder
Storage	4°C, protect from light * In solvent : -80°C, 6 months -20°C, 1 month (protect from light)
Complexity	400
Exact Mass	288.06338810
Index Of Refraction	1.725
In Vitro	Eriodictyol is a flavonoid isolated from the Chinese herb, with antioxidant and anti-inflammatory activity. Eriodictyol (20, 40, 80 μM) protects primary cultured cortical neurons against Aβ25-35-induced cytotoxicity and cell Apoptosis via the Nrf2/ARE pathway. Eriodictyol (80 μM) induces nuclear expression of Nrf2 and the expression of ARE-regulated genes in primary cultured cortical neuron.
In Vivo	Eriodictyol shows protective effect against LPS-induced acute lung injury (ALI). Eriodictyol (30 mg/kg, p.o.) decreases the production of inflammatory cytokines, elevates survival rate, and decreases oxidative stress levels in LPS-induced ALI mice. Eriodictyol inhibits MPO activity and inflammatory neutrophil accumulation in the lung tissues. Eriodictyol treatment also enhances Trx1 expression by upregulating the Nrf2 expression in lung tissues.
PSA	107.22000
Target	Keap1-Nrf2; Influenza Virus; DNA/RNA Synthesis; Endogenous Metabolite
Vapor Pressure	0.0±1.9 mmHg at 25°C
XLogP3-AA	2