-
Antiviral API
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Emivirine
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| Category | Human immunodeficiency Virus (HIV) |
| CAS | 149950-60-7 |
| Description | Emivirine (MKC-442) is a non-nucleoside reverse transcriptase inhibitors (NNRTIs) with Ki values of 0.20 and 0.01 μM for dTTP- and dGTP-dependent DNA or RNA polymerase activity, respectively. Emivirine displays potent and selective anti-human immunodeficiency virus type 1 (HIV-1) activity. |
Product Information
| Synonyms | Emivirine; Coactinon; MKC-442; I-EBU; 149950-60-7; 6-BENZYL-1-ETHOXYMETHYL-5-ISOPROPYLURACIL |
| IUPAC Name | 6-benzyl-1-(ethoxymethyl)-5-propan-2-ylpyrimidine-2,4-dione |
| Molecular Weight | 302.372 |
| Molecular Formula | C17H22N2O3 |
| Canonical SMILES | CCOCN1C(=C(C(=O)NC1=O)C(C)C)CC2=CC=CC=C2 |
| InChI | InChI=1S/C17H22N2O3/c1-4-22-11-19-14(10-13-8-6-5-7-9-13)15(12(2)3)16(20)18-17(19)21/h5-9,12H,4,10-11H2,1-3H3,(H,18,20,21) |
| InChIKey | MLILORUFDVLTSP-UHFFFAOYSA-N |
| Purity | 95% |
| Density | 1.133g/cm3 |
| Solubility | In vitro: 10 mM in DMSO |
| Appearance | Solid powder |
| Application | Reverse Transcriptase Inhibitors |
| Storage | Store at -20°C |
| Complexity | 451 |
| Exact Mass | 302.16304257 |
| In Vitro | Emivirine (EMV) is also specific for HIV-1 RT and was without effect on HIV-2 Emivirine (EMV) has no obvious toxicity for human healthy cells Cell Viability Assay Cell Line: Human bone marrow cells collected from normal healthy volunteers Concentration: 0, 0.1, 1, 10, or 100 μM Incubation Time: 14 days Result: At concentrations of 0.1 to 10 μM, no effect on cell growth, lactic acid production, mitochondrial DNA synthesis, or mitochondrial structure was seen compared to what occurred with untreated HepG2 cells. |
| In Vivo | Tthe approximate lethal oral dose of Emivirine (EMV) for rats was ≥3 g/kg for males and 2.5 g/kg for females |
| PSA | 64.09000 |
| Target | HIV |
| XLogP3-AA | 2.6 |
