Elvitegravir-d8

Category	HIV Integrase
Description	Elvitegravir-d8 is deuterium labeled Elvitegravir. Elvitegravir (GS-9137, JTK-303) is an HIV integrase inhibitor for HIV-1 IIIB , HIV-2 EHO and HIV-2 ROD with IC50 of 0.7 nM, 2.8 nM and 1.4 nM in cell-free assays, respectively.

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Synonyms	GS-9137-d8; JTK-303-d8; D06677-d8
Molecular Weight	455.93
Molecular Formula	C23H15D8ClFNO5
Canonical SMILES	OCC(N1C2=CC(OC)=C(CC3=C(C(Cl)=CC=C3)F)C=C2C(C(C(O)=O)=C1)=O)([2H])C(C([2H])([2H])[2H])([2H])C([2H])([2H])[2H]
Boiling Point	658.8±55.0 °C at 760 mmHg
Flash Point	352.2±31.5 °C
Purity	≥98% (HPLC)
Density	1.4±0.1 g/cm3
Solubility	In vitro: 10 mM in DMSO
Appearance	Solid powder
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Complexity	702
Exact Mass	455.1750927
Index Of Refraction	1.619
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and Metabolic profiles of drugs.
Target	IC50: 0.7 nM (HIV-1IIIB), 2.8 nM (HIV-2EHO), 1.4 nM(HIV-2ROD)
Vapor Pressure	0.0±2.1 mmHg at 25°C
XLogP3-AA	5.3