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Antiviral API
- Arenavirus
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- Endogenous Metabolite
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- Antiviral intermediates
EHNA hydrochloride
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| Category | Influenza Virus |
| CAS | 58337-38-5 |
| Description | EHNA hydrochloride is a selective inhibitor of cGMP-stimulated phosphodiesterase (PDE2) (IC50 = 0.8 - 4 μM) and also an inhibitor of adenosine deaminase. EHNA inhibits spontaneous differentiation of human ESCs in feeder-free conditions and directed neuronal differentiation. |
Product Information
| Synonyms | (2S,3R)-3-(6-aminopurin-9-yl)nonan-2-ol hydrochloride |
| IUPAC Name | (2R,3S)-3-(6-aminopurin-9-yl)nonan-2-ol;hydrochloride |
| Molecular Weight | 313.83 |
| Molecular Formula | C14H23N5O.HCl |
| Canonical SMILES | CCCCCCC(C(C)O)N1C=NC2=C1N=CN=C2N.Cl |
| InChI | InChI=1S/C14H23N5O.ClH/c1-3-4-5-6-7-11(10(2)20)19-9-18-12-13(15)16-8-17-14(12)19;/h8-11,20H,3-7H2,1-2H3,(H2,15,16,17);1H/t10-,11+;/m0./s1 |
| InChIKey | VVDXNJRUNJMYOZ-VZXYPILPSA-N |
| Boiling Point | 478.2°C at 760 mmHg |
| Melting Point | 163-180°C |
| Flash Point | 243°C |
| Purity | >98% |
| Density | 1.27g/cm3 |
| Solubility | In Vitro: DMSO : ≥ 250 mg/mL(796.61 mM) H2O : 100 mg/mL(318.64 mM;Need ultrasonic) In Vivo: 1.Add each solvent one by one:10% DMSO >> 40%PEG300 >> 5%Tween-80 >> 45% saline Solubility: ≥ 2.08 mg/mL (6.63 mM); Clear solution 2.Add each solvent one by one:10% DMSO >> 90% (20%SBE-β-CDin saline) Solubility: ≥ 2.08 mg/mL (6.63 mM); Clear solution 3.Add each solvent one by one:10% DMSO >> 90%corn oil Solubility: ≥ 2.08 mg/mL (6.63 mM); Clear solution |
| Appearance | Off-white to Light Pink Solid |
| Application | Antiviral Agents |
| Storage | -20°C, sealed storage, away from moisture * In solvent : -80°C 6 months; -20°C 1 month (sealed storage, away from moisture) |
| Index Of Refraction | 1.628 |
| In Vitro | EHNA completely ablates the ability of cyclic GMP to activate PDE2 activity, whilst having a much smaller inhibitory effect on the unstimulated PDE2 activity. EHNA exhibits normal Michaelian kinetics of inhibition for the cyclic GMP-stimulated PDE2 activity with Hill plots near unity. EHNA prevents dAdo degradation and increases mitochondrial dATP levels in fibroblasts |
| PSA | 89.85000 |
| Target | Adenosine Deaminase; Phosphodiesterase (PDE); Influenza Virus |
