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EFdA-TP-tetraammonium

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Category Human immunodeficiency Virus (HIV)
Description EFdA-TP tetraammonium is a potent nucleoside reverse transcriptase (RT) inhibitor. EFdA-TP tetraammonium inhibits RT-
catalyzed DNA synthesis as an effective immediate or delayed chain terminator (ICT or DCT). EFdA-TP tetraammonium
inhibits HIV-1 RT with multiple mechanisms
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Product Information

Synonyms EFdA-TP tetraammonium
Molecular Weight 601.32
Molecular Formula C12H27FN9O12P3
Purity 98.03%
Solubility In vitro:
10 mM in DMSO
Appearance Off-white to light yellow (Solid)
Storage -20°C, sealed storage, away from moisture and light
* In solvent :
-80°C 6 months;
-20°C 1 month (sealed storage, away from moisture and light)
In Vitro EFdA-TP tetraammonium (0.05-10 μM; for 15 min) inhibits RT-catalyzed DNA synthesis as an ICT or DCT.
EFdA-TP tetraammonium can block RT as a translocation-defective RT inhibitor that dramatically slows DNA synthesis, acting as a de facto immediate chain terminator. EFdA-TP tetraammonium can function as a delayed chain terminator, allowing incorporation of an additional dNTP before blocking DNA synthesis.
Target Reverse Transcriptase; DNA/RNA Synthesis; HIV

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